Dr LU Gang - School of Biomedical Sciences, CUHK

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Dr LU Gang

Senior Research Fellow

B.Med. (Clinic), M.D. (Surgery)

39435739

lugang@cuhk.edu.hk

Rm 124A, 1/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

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Research Interests

Neural Regenerative Medicine
Cell Therapeutic Strategies for Clinical Application
Innovative Technologies for Disease Diagnosis

Publications

Cao LB, Liu HB, Lu G.^*, Lv Y, Leung CK, Du YZ, Wang WM, Xiong ZQ, Su XW, Li HJ, Chen ZJ, Ma JL, & Chan WY. (2020). Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development. Front Cell Dev Biol. , 8:587, PMID: 32850784.
Wang W, Lu G.^*, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL,Cheung HH, Kung HF, Chen ZJ, & Chan WY. (2020). Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. , 7; 11(2):107.
Liu Y, Lu G.^*, Su XW, Ding T, Wang WL, Li YM, Poon WS, & Ao LJ. (2018). Characterization of Axon Damage, Neurological Deficits, and Histopathology in Two Experimental Models of Intracerebral Hemorrhage. Front. Neurosci. , 12:928.
Zeng XF, Li Q, Li J, Wong N, Li Z, Huang J, Yang G, Sham PC, Li SB, & Lu G.^*. (2018). HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett. , 299, 159-171.
Wang Z, Lu G.^#, Sze J, Liu Y, Lin S, Yao H, Zhang J, Xie D, Liu Q, Kung HF, Lin MC, & Poon WS. (2017). Plasma miR-124 Is a Promising Candidate Biomarker for Human Intracerebral Hemorrhage Stroke. Mol Neurobiol, 55:5879–5888.
Lv Y., Zhao S.G., Lu G.^*, Leung C.K., Xiong Z.Q., Su X.W., Ma J.L., Chan W.Y., & Liu H.B. (2017). Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients. Sci Rep, 7(1):6961.
Su X.W.,Lu G.^*, Leung C.W., Liu Q., Li Y.,Tsang K.S., Zhao S.D., Chan D.T.M., Kung H.F., & Poon W.S. (2017). miR-181d Regulates Human Dendritic Cell Maturation through NF-κB Pathway. Cell Prolif, doi: 10.1111/cpr.12358.
Lu G., Wong M.S., Xiong M.Z.Q., Leung C.K., Su X.W., Zhou J.Y., Poon W.S., Zheng V.Z.Y., Chan W.Y., & Wong G.K.C. (2017). Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc, 6:4.
Wang W.M., Lu G.^#, Su X.W., Lyu H., & Poon W.S. (2017). MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway. Front Cell Neurosci, 11:96.
Liu P.C., Lu G.^#, Deng. Y., Wang C.D., Su X.W., Zhou J.Y., Chan T.M., Hu X., & Poon W.S. (2017). Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy. PLoS ONE, 12(1):e0171157.
Liu Y., Ao L.J., Lu G.^*, Leong E., Liu Q., Wang X.H., Zhu X.L., Sun T.F., Fei Z., Jiu T., Hu X., & Poon W.S. (2013). Quantitative gait analysis of long-term locomotion deficits in classical unilateral striatal intracerebral hemorrhage rat model. Behav Brain Res, 257: 166-77.
Wang X.H., Lu G.^#, Hu X., Tsang K.S., Kwong W.H., Wu F.X., Meng H.W., Jiang S., Liu S.W., Ng H.K., & Poon W.S. (2012). Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson’s disease. BMC Neurosci, 13:142.
Zhang J.F., Fu W.M., He M.L., Wang H., Wang W.M., Yu S.C., Bian X.W., Zhou J., Lin M.C., Lu G.^*, & Poon W.S., Kung H.F. (2011). MiRNA-637 Maintains the Balance between Adipocyte and Osteoblast by Directly Targeting Osterix. Molecular Biology of the Cell,22 (21):3955-3961.
Li Q., Lu G.^#, Kwong W.H., Choi H.L., Zeng X.F., Li Z., Yew D.T., & Poon W.S. (2011). Programmed Neuronal Cell Death Induced by HIV-1 Tat and Methamphetamine. Microscopy Research and Technique, 74(12):1139-44.
Li Q., Lu G., Antonio G.E., Mak Y.T., Rudd J.A., Fan M., & Yew D.T. (2007). The usefulness of the spontaneously hypertensive rat to model attention-deficit / hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Neurochem Int, 50(6):848-57.
Lu G., Wu Y., Mak Y.T., Wai S.M., Feng Z.T., Rudd J.A., & Yew D.T. (2006). Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8. Brain Res, 1090(1):23-28.
Poon W.S., Lu G., Tsang K.S., Zhu X.L., Chen G., & Ng H.K. (2006) Migration of bone marrow stem cells in ischaemic brain. Acta Neurochir Suppl, 99:123-124.
Lu G., Wai S.M., Poon W.S., & Yew D.T. (2005). Ki67 and doublecortin positive cells in human prefrontal cortices of normal aging and vascular dementia. Microscopy Research and Technique, 68(5):255-257.
Lu G., Mak Y.T., Wai S.M., Kwong W.H., Fang M., James A., Randall D., & Yew D.T. (2005). Hypoxia-induced differential apoptosis in the central nervous system of the sturgeon. Microscopy Research and Technique, 68(5):258-63.
Lu G., Kwong W.H., Li Q., Wang X., Feng Z., & Yew D.T. (2005). bcl2, bax, and nestin in the brains of patients with neurodegeneration and those of normal aging. J Mol Neurosci, 27(2):167-174.* Co-corresponding author
^# Co-first author

Grants

Innovation and Technology Support Programme [PI; 01-Nov-2019 to 31-Oct-2021]: “Study of circulating miRNAs in prediction of stroke risk after transient ischemic attack” (HK$1,627,940).
Innovation and Technology Support Programme [PI; 01-Mar-2018 to 30-Sep-2020]: “Enrichment of Extracellular Vesicles Secreted by Human-induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Ischemic Stroke” (HK$1,299,500).
CUHK One-off Funding for Hong Kong Branch of Chinese National Engineering Research Centers [PI; 01-Jul-2015 to 30-Jun-2017]: “Center for Assisted Reproductive Technology and Reproductive Genetics” (HK$330,000).
Innovation and Technology Support Programme [PI; 01-Jul-2013 to 30-Jun-2015]: “Development of TRAIL-secreting Umbilical Cord Mesenchymal Stem Cells for Glioblastoma Treatment” (HK$990,000).
Ministry of Science and Technology – National High-Tech Research and Development Program of China [Co-PI; 2012 to 2015]: “R&D and large – scale manipulation of cell products for immunotherapy” (CND2,760,000).