張凱鴻教授 - 生物醫學學院

張凱鴻教授

助理教授

39439796

cheunghh@cuhk.edu.hk

https://cheunglab.weebly.com/

707A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Publons

ORCID

個人簡介

Prof. CHEUNG Hoi Hung Albert (張凱鴻) obtained his Ph.D degree from The Chinese University of Hong Kong (CUHK) in 2010. He received his pre-doctoral and post-doctoral training at the National Institutes of Health (NIH) in the United States. He joined the School of Biomedical Sciences, CUHK, as a Research Assistant Professor in 2014, and became an Assistant Professor in 2019. His research interests include understanding the molecular mechanisms that control stem cell homeostasis and aging. He focuses on studying the roles of RecQ DNA helicases and DEAD-box RNA helicases in stem cell senescence, renewal, and differentiation. He also studies the diseases associated with the loss or mutation of these helicases using animal, iPSC, and iPSC-derived organoid models.

研究興趣

The role of RecQ helicases in stem cell aging and premature aging diseases (Werner syndrome, Bloom syndrome).
The role of DExD/H-box RNA helicases in stem cell self-renewal and aging.
Disease modeling by organoids.

著作選錄

Yiu, T.C., Tu, J. & Cheung, H.H. (2025). An overview of RecQ helicases and related diseases. Aging (Albany NY), 17(7). doi: 10.18632/aging.206291.
Lautrup, S., Zhang, S.Q., Funayama, S., Lirussi, L., Visnovska,T., Cheung, H.H., Niere, M., Tian,Y., Nilsen, H.L., Selbaek, G., Saarela, J., Maezawa, Y., Yokote, K., Nilsson, P., Chan, W.Y., Kato, H., Ziegler, M., Bohr, V.A., & Fang, E.F. (2025). Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation. Aging (Albany NY), 7(4): p. 937-959. doi: 10.18632/aging.206236.
Tam, H.Y., Liu, J., Yiu, T.C., Leung, A.O., Li, C., Gu, S., Rennert, O., Huang, B. & Cheung, H.H. (2025). Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway. Cell Biosci, 15(1): p. 10. doi:10.1186/s13578-025-01355-4.
Xia, W., Liu, Y., Lu, J., Cheung, H.H., Meng, Q. & Huang, B. (2024). RNA methylation in neurodevelopment and related diseases. Acta Biochim Biophys Sin (Shanghai), 56(12): p. 1723-1732. doi: 10.3724/abbs.2024159.
Lu, J., Zhang, M., Liu, Z., Guo, L., Huang, P., Xia, W., Li, J., Lv, J., Cheung, H.H., Ding, C., Li, H. & Huang, B. (2024). NSUN2-Mediated m(5)C Methylation Impairs Endometrial Receptivity. Lab Invest, 104(4): p. 100327. doi:10.1016/j.labinv.2024.100327.
Calame, D.G., Guo,T., Wang, C., Garrett, L., Jolly, A., Dawood, M., Kurolap, A., Henig, N.Z., Fatih, J.M., Herman, I., Du, H., Mitani, T., Becker, L., Rathkolb, B., Gerlini, R., Seisenberger, C., Marschall, S., Hunter, J.V., Gerard, A., Heidlebaugh, A., Challman, T., Spillmann, R.C., Jhangiani, S.N., Coban-Akdemir, Z., Lalani, S., Liu, L., Revah-Politi, A., Iglesias, A., Guzman, E., Baugh, E., Boddaert, N., Rondeau, S., Ormieres, C., Barcia, G., Tan, Q.K.G., Thiffault, I., Pastinen, T., Sheikh, K., Biliciler, S., Mei, D., Melani, F., Shashi, V., Yaron, Y., Steele, M., Wakeling, E., Ostergaard, E., Nazaryan-Petersen, L., Millan, F., Santiago-Sim, T. , Thevenon, J., Bruel, A.L., Thauvin-Robinet, C. , Popp, D., Platzer, K., Gawlinski, P. , Wiszniewski, W., Marafi, D., Pehlivan, D., Posey, J.E., Gibbs, R.A., Gailus-Durner, V., Guerrini, R., Fuchs, H., Angelis, Hrabe de, Holter, S.M., Cheung, H.H., Gu, S. & Lupski, J.R. (2023). Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease. Am J Hum Genet, 110(8): p. 1394-1413. doi:10.1016/j.ajhg.2023.06.013.
Leung, A.O., Yiu, T.C., Liu, L., Tam, H.Y., Gu, S., Tu, J., Pei, D. & Cheung, H.H. (2022). Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Cell Biosci, 12(1): p. 212. doi: 10.1186/s13578-022-00939-8.
Hou, Y., Li, C., Yoon, C., Leung, O.W., You, S., Cui, X., Chan, J.F., Pei, D., *Cheung, H.H. & *Chu, H. (2022). Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids. Signal Transduct Target Ther, 7(1): p. 38. doi: 10.1038/s41392-022-01241-2.
Tian, Y., Wang, W., Lautrup, S. , Zhao, H., Li, X., Law, P.W.N., Dinh, N.D., Fang, E.F., *Cheung, H.H. & Chan, W.Y. (2022). WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nat Commun, 2022. 13(1): p. 5456. doi: 10.1038/s41467-022-33012-6.
Wang, Z., Miu, K.K., Zhang, X., Wan, T.Y., Lu, G., Cheung, H.H., Lee, H.M., Kong, P.S., Chan, J.C.N. & Chan, W.Y. (2020). Hepatic miR-192-3p re-activation alleviates steatosis by targeting glucocorticoid receptor. JHEP Reports, Dec: 2(6). doi: 10.1016/j.jhepr.2020.100179.
Wang, W., Lu, G., Su, X., Tang, C., Li, H., Xiong, Z., Leung, C.K., Wong, M.S., Liu, H., Ma, J.L., Cheung, H.H., Kung, H.F., Chen, Z.J., & Chan, W.Y. (2020). Pten-mediated Gsk3β Modulates the Naïve Pluripotency Maintenance in Embryonic Stem Cells. Cell Death Dis, Feb 7; 11(2):107. doi: 10.1038/s41419-020-2271-0.
Tu, J., Wan, C., Zhang, F., Cao, L., Law, W.N., Tian, Y., Gang, L., Rennert, O.M., Chan, W.Y., & Cheung, H.H.* (2020). Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell, May; 19(5):e13116. doi: 10.1111/acel.13116.
Liu, Z.H. & Cheung, H.H. (2020). Stem Cell-Based Therapies for Parkinson Disease. Int. J. Mol. Sci.,, 21(21):8060. doi: 10.3390/ijms21218060.
Tu, J., Cheung, H.H., Lu, G., Chan, C.L., Chen, Z.J., & Chan, W.Y. (2019). microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7. Frontier in Oncology, 9, 486. doi: 10.3389/fonc.2019.00486.
Tu, J., Cheung, H.H., Chan, L.K., & Chan, W.Y. (2019). The Role of microRNAs in Ovarian Granulosa Cells in Health and Diseases. Frontiers in Endocrinology, 10, 174. doi: 10.3389/fendo.2019.00174.
Lautrup, S., Caponio, D., Cheung, H.H, Piccoli, C., Stevnsner, T., Chan, W.Y., & Fang, E.F. (2019). Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology, 20(3), 255-269. doi: 10.1007/s10522-019-09798-2.
Cao, D., Cheung, H.H., & Chan, W.Y. (2019). Doxycycline masks the genuine effect of the doxycycline-inducible transgene by promoting dopaminergic neuron differentiation from human pluripotent stem cells. Stem Cells and Development, 28(13), 833-845. doi: 10.1089/scd.2018.0209.
Tu, J.J., Zhang, P., Luk, A.C.S., Liao, J.J.Y., Chan, W.Y., Cheung, H.H.*, & Lee, T.L.* (2018). MicroRNA-26b promotes transition from Kit- to Kit+ mouse spermatogonia. Experimental Cell Research, 373(1-2), 71-79. doi: 10.1016/j.yexcr.2018.09.018.
Tu, J.J., Tian, G., Cheung, H.H., Wei, W., & Lee, T.L. (2018). Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Research & Therapy, 9(1), 71. doi: 10.1186/s13287-018-0813-5.
Tu, J.J., Cheung, H.H., Lu, G., Chen, Z., & Chan, W.Y. (2018). MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis. Cell Death & Disease, 9(11), 1076. doi: 10.1038/s41419-018-1117-5.
Tu, J.J., Cao, D., Li, L., Cheung, H.H.*, & Chan, W.Y.* (2018). MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells. FEBS Open Bio, 8(4), 502-512. doi: 10.1002/2211-5463.12377.
Li, L., Miu, K.K., Gu, S., Cheung, H.H.*, & Chan, W.Y.* (2018). Comparison of multi-lineage diferentiation of hiPSCs reveals novel miRNAs that regulate lineage specification. Scientific Reports, 8(1), 9630. doi:10.1038/s41598-018-27719-0.
Liu, X., Campanac, E., Cheung, H.H., Ziats, M.N., Canterel-Thouennon, L., Raygada, M., Baxendale, V., Pang, A.L., Yang, L., Swedo, S., Thurm, A., Lee, T.L., Fung, K.P., Chan, W.Y., Hoffman, D.A., & Rennert, O.M. (2016). Idiopathic Autism: Cellular and Molecular Phenotypes in Pluripotent Stem Cell-Derived Neurons. Molecular Neurobiology, 54(6), 4507-4523.
Tu, J.J., Yang, Y., Cheung, H.H., Chen, Z.J., & Chan, W.Y. (2017). Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Scientific Reports, 7, 41304. doi: 10.1038/srep41304.
Yang, Y., Cheung, H.H., Tu, J.J., Miu, K.K., & Chan, W.Y. (2016). New insights into the unfolded protein response in stem cells. Oncotarget, 7(33), 54010-54027.
Yang, Y., Cheung, H.H., Law, W.N., Zhang, C., Chan, W.Y., Pei, X., & Wang, Y. (2016). New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification. Biology of Reproduction, 94(6), 137.
Cheung, H.H., Yang, Y., Lee, T.L., Rennert, O., & Chan, W.Y. (2016). Hypermethylation of genes in testicular embryonal carcinomas. British Journal of Cancer, 114(2), 230-6.
Cheung, H.H., Pei, D., & Chan, W.Y. (2015). Stem cell aging in adult progeria. Cell Regen (Lond), 4, 6. doi: 10.1186/s13619-015-0021-z. eCollection 2015
Cheung, H.H., Liu, X., Canterel-Thouennon, L., Li, L., Edmonson, C., & Rennert, O.M. (2014). Telomerase protects Werner Syndrome lineage-specific stem cells from premature aging. Stem Cell Reports, 2(4), 534-46.
Gu, S., Cheung, H.H., Lee, T.L., Lu, G., Poon, W.S., & Chan, W.Y. (2013). Molecular Mechanisms of Regulation and Action of microRNA-199a in Testicular Germ Cell Tumor and Glioblastomas. PLoS One, 8(12), e83980.
Cheung, H.H., Liu, X., & Rennert, O.M. (2012). Apoptosis: Reprogramming and the Fate of Mature Cells. ISRN Cell Biology, 2012, 685852.
Cheung, H.H., & Rennert, O.M. (2011). Generation of fertile sperm in a culture dish: clinical implications. Asian Journal of Andrology, 13(4), 618-9.
Cheung, H.H., Davis, A.J., Lee, T.L., Pang, A.L., Nagrani, S., Rennert, O.M., & Chan, W.Y. (2011). Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene, 30(31), 3404-15.
Lee, T.L., Li, Y., Cheung, H.H., Claus, J., Singh, S., Sastry, C., Rennert, O.M., Lau, Y.F., & Chan, W.Y. (2010). GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics, 26(4), 585-6.
Cheung, H.H., Lee, T.L., Davis, A.J., Taft, D.H., Rennert, O.M., & Chan, W.Y. (2010). Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. British Journal of Cancer, 102(2), 419-27.
Lee, T.L., Cheung, H.H., Claus, J., Sastry, C., Singh, S., Vu, L., Rennert, O., & Chan, W.Y. (2009). GermSAGE: a comprehensive SAGE database for transcript discovery on male germ cell development. Nucleic Acids Research, 37(Database issue), D891-7.
Cheung, H.H., Lee, T.L., Rennert, O.M., & Chan, W.Y. (2009). DNA methylation of cancer genome. Birth Defects Res C Embryo Today, 87(4): 335-50.
Co, N.N., Tsang, W.P., Wong, T.W., Cheung, H.H., Tsang, T.Y., Kong, S.K., & Kwok, T.T. (2008). Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. Molecular Cancer Therapeutics, 7(10), 3160-8.
Tsang, W.P., Wong, T.W., Cheung, H.H., Co, C.N., & Kwok, T.T. (2007). Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA, 13(6), 890-8.

* Corresponding / Co-corresponding author

研究資助

RGC – General Research Fund [PI; 01-Jan-23 to 31-Dec-25]: “A zebrafish model for studying RecQ helicase disorders”.
RGC – General Research Fund [PI; 01-Jan-22 to 31-Dec-24]: “Elucidating the role of nucleolar RNA helicase DDX21 in neurodegeneration”.
RGC – General Research Fund [PI; 01-Jan-21 to 31-Dec-23]: “Studying the mechanism of WRN for causing short stature in Werner syndrome”.
Health@InnoHK Fund [Co-PI; 01-May-20 to 30-April-25]: “Generation of Epithelial Stem Cell for Skin Regeneration”.
RGC – General Research Fund [PI; 01-Jan-19 to 31-Dec-21]: “Impaired pro-angiogenesis in mesenchymal stem cells of Werner syndrome: Implication in premature vascular aging”.
RGC – General Research Fund [PI; 01-Jan-18 to 31-Dec-20]: “The function of a primate-specific microRNA-1202 in dopaminergic neurons”.
National Natural Science Foundation of China (NSFC) – Young Scientist Fund [PI; 01-Jan-17 to 31-Dec-19]: “The Role and Mechanism of Endoplasmic Reticulum Stress in the Aging of Mesenchymal Stem Cells”.