高波教授 - 生物醫學學院

高波教授

副教授

Ph.D.

39436801

bogao@cuhk.edu.hk

https://www.gaobolab.com/

604A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

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個人簡介

Prof. GAO Bo (高波) is an Associate Professor of the School of Biomedical Sciences of the Faculty of Medicine at the Chinese University of Hong Kong (CUHK). He obtained his bachelor and doctoral degrees from the Shanghai Jiao Tong University, where he received the academic training in the fields of human genetics and developmental genetics. After completing his postdoctoral training at National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), he worked in the same institute as staff scientist. He then set up his own laboratory at the University of Hong Kong, where his research mainly focused on cell signaling in development and disease with a special interest in skeletal disorders. In 2023, he joined CUHK and expanded his research to broader areas of cell biology, developmental biology, and skeletal biology. Prof. Gao has published in leading international journals including Nature, Nature Genetics, Developmental Cell, Journal of Clinical Investigation, Cell Research, Science Advances, Nature Communications, PNAS, and Development as first and/or corresponding authors. He has received a number of academic honors and awards, including Dr Cheng Yu Tung Fellowship, Shanghai Youth Science and Technology Innovation Mayor Award, Second-Class Prize of National Natural Science Award, National Youth Science and Technology Innovation Award, NIH The Fellows Award for Research Excellence, NHGRI Intramural Research Training Award, NIH Genome Recognition of Employee Accomplishments and Talents (GREAT) Award, and Chinese Medical Science and Technology Award for Youths.

研究興趣

Skeletal Biology and Skeletal Disorders
Wnt/Planar Cell Polarity (Wnt/PCP) signaling
ER Biology

著作選錄

Selected publications as first/corresponding/co-corresponding authors.

Feng, X., Ye, Y., Zhang, J., Zhang, Y., Zhao, S., Mak, J.C.W., Otomo, N., Zhao, Z., Niu, Y., Yonezawa, Y., Li, G., Lin, M., Li, X., Cheung, P.W.H., Xu, K., Takeda, K., Wang, S., Xie, J., Kotani, T., Choi, V.N.T., Song, Y.Q., Yang, Y., Luk, K.D.K., Lee, K.S., Li, Z., Li, P.S., Leung, C.Y.H., Lin, X., Wang, X., Qiu, G. DISCO (Deciphering disorders Involving Scoliosis and COmorbidities) study group, Watanabe K, Japanese Early Onset Scoliosis Research Group, Wu, Z., Posey, J.E., Ikegawa, S., Lupski, J.R., Cheung, J.P.Y., Zhang, T.J., Gao, B. & Wu, N. (2024). Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations. Proc. Natl. Acad. Sci. U.S.A. ,121(18):e2310283121.
Wang, X., Yue, M., Cheung, J.P.Y., Cheung, P.W.H., Fan, Y., Wu, M., Wang, X., Zhao, S., Khanshour, A.M., Rios, J.J., Chen, Z., Wang, X., Tu, W., Chan, D., Yuan, Q., Qin, D., Qiu, G., Wu, Z., Zhang, T.J., Ikegawa, S., Wu, N., Wise, C.A., Hu, Y., Luk, K.D.K., Song, Y.Q. & Gao, B. (2024). Impaired glycine neurotransmission causes adolescent idiopathic scoliosis. Journal of Clinical Investigation, 134(2): e168783.
Feng, D., Wang, J., Yang, W., Li, J., Lin, X., Zha, F., Wang, X., Ma, L., Choi, N.T., Mii, Y., Takada, S., Huen, M.S.Y., Guo, Y., Zhang, L. & Gao, B. (2021). Regulation of Wnt/PCP Signaling through p97/VCP-KBTBD7-mediated Vangl Ubiquitination and Endoplasmic Reticulum-Associated Degradation. Science Advances, 7(20):eabg2099.
Li, C., Wang, N., Schaffer, A.A., Liu, X., Zhao, Z., Elliott, G., Garrett, L., Choi, N.T., Wang, Y., Wang, Y., Wang, C., Wang, J., Su, P., Chan, D., Cui, S., Yang, Y. & Gao, B. (2020). Mutations in COMP cause familial carpal tunnel syndrome. Nature Communications, 11(1):3642.
Yang, W., Garrett, L., Feng, D., Elliott, G., Liu, X., Wang, N., Wong, Y.M., Choi, N.T., Yang, Y. & Gao, B. (2017). Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Research,27(12):1466-1484.
Gao, B., Ajima, R., Yang, W., Li, C., Song, H., Anderson, M.J., Liu, R.R., Lewandoski , M.B., Yamaguchi, T.P. & Yang, Y. (2018). Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity. Development, 145(8).
Gao, B. & Yang, Y. (2013). Planar Cell Polarity in vertebrate limb morphogenesis. Curr Opin Genet Dev., 23(4):438-44.
Gao, B. (2012). Wnt Regulation of Planar Cell Polarity (PCP). Curr Top Dev Biol., 101:263-295.
Gao, B., Song, H., Bishop, K., Elliot, G., Garrett, L., English, M., Andre, P, Robinson, J., Sood, R., Minami, Y., Economides, A & Yang, Y. (2011). Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Developmental Cell, , 20(2):163-176.
Gao, B., Hu, J., Stricker, S., Cheung, M., Ma, G., Law, K., Witte, F., Briscoe, J., Mundlos, S., He, L., Cheah, K. & Chan, D. (2009). A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature, 458(7242):1196-200.
Gao, B. & He, L. (2004). Answering a century old riddle: brachydactyly type A1. Cell Research, 14(3):179-87.
Gao, B., Guo, J., She, C., Shu, A., Yang, M., Tan, Z., Yang, X., Guo, S., Feng, G. & He, L. (2001). Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nature Genetics, 28(4):386-8.

研究資助

RGC – General Research Fund[PI; 01-Jan-25]: “Elucidating the role of the Vangl-Vrk2 signaling axis in the regulation of ER morphology” (HK $1,559,580).
RGC – General Research Fund [PI; 01-Jan-23]: “A Novel Protein Quality Control Mechanism in Regulating Core Planar Cell Polarity Protein Vangl2 and Beyond” (HK $1,180,218).
RGC – General Research Fund [PI; 01-Jan-22]: “Investigating the role of Vangl2 phosphorylation at the C-terminal PDZ-binding motif” (HK $1,075,732).
RGC – General Research Fund [PI; 01-Jan-21]: “Elucidating the role of USP6/32 in Wnt/PCP signaling” (HK $1,195,542).
RGC – General Research Fund [PI; 01-Sept-19]: “Elucidating the role of CUL3-KBTBD6/7 in regulating Vangl2 ubiquitination and PCP signaling” (HK $1,116,019).
RGC – Early Career Scheme [PI; 01-July-17]: “Regulation of non-canonical Wnt/PCP signaling by Vangl2 phosphorylation” (HK $1,313,444).
Health and Medical Research Fund [PI; 30-Jan-22]: “The role of ECM mutations as predisposing factors for Carpal Tunnel Syndrome” (HK $1,499,848).
Health and Medical Research Fund [PI; 01-Sept-20]: “Genetic Diagnosis and Research of Osteogenesis Imperfecta” (HK $1,499,870).
Health and Medical Research Fund [PI; 01-June-19]: “Identifying the Genetic Factors underlying Congenital Scoliosis in Hong Kong” (HK $1,499,752).
Health and Medical Research Fund [PI; 01-March-18]: “Understanding the Molecular Basis of Carpal Tunnel Syndrome” (HK $1,195,048).
National Natural Science Foundation – General Program [PI; 01-Jan-22]: “The molecular mechanism of deubiquitinases in the regulation of planar cell polarity signaling” (RMB $580,000).
National Natural Science Foundation – General Program [PI; 01-Jan-18]: “Elucidating the role of post-translational modification of planar cell polarity core protein Vangl2 in Wnt/PCP signaling pathway” (RMB $580,000).