路鋼博士 - 生物醫學學院

路鋼博士

高級研究員

B.Med. (Clinic), M.D. (Surgery)

39435739

lugang@cuhk.edu.hk

Rm 124A, 1/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Google Scholar

研究興趣

Neural Regenerative Medicine
Cell Therapeutic Strategies for Clinical Application
Innovative Technologies for Disease Diagnosis

選錄

Cao LB, Liu HB, Lu G.^*, Lv Y, Leung CK, Du YZ, Wang WM, Xiong ZQ, Su XW, Li HJ, Chen ZJ, Ma JL, & Chan WY. (2020). Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development. Front Cell Dev Biol. , 8:587, PMID: 32850784.
Wang W, Lu G.^*, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL,Cheung HH, Kung HF, Chen ZJ, & Chan WY. (2020). Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. , 7; 11(2):107.
Liu Y, Lu G.^*, Su XW, Ding T, Wang WL, Li YM, Poon WS, & Ao LJ. (2018). Characterization of Axon Damage, Neurological Deficits, and Histopathology in Two Experimental Models of Intracerebral Hemorrhage. Front. Neurosci. , 12:928.
Zeng XF, Li Q, Li J, Wong N, Li Z, Huang J, Yang G, Sham PC, Li SB, & Lu G.^*. (2018). HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling. Toxicol Lett. , 299, 159-171.
Wang Z, Lu G.^#, Sze J, Liu Y, Lin S, Yao H, Zhang J, Xie D, Liu Q, Kung HF, Lin MC, & Poon WS. (2017). Plasma miR-124 Is a Promising Candidate Biomarker for Human Intracerebral Hemorrhage Stroke. Mol Neurobiol, 55:5879–5888.
Lv Y., Zhao S.G., Lu G.^*, Leung C.K., Xiong Z.Q., Su X.W., Ma J.L., Chan W.Y., & Liu H.B. (2017). Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients. Sci Rep, 7(1):6961.
Su X.W.,Lu G.^*, Leung C.W., Liu Q., Li Y.,Tsang K.S., Zhao S.D., Chan D.T.M., Kung H.F., & Poon W.S. (2017). miR-181d Regulates Human Dendritic Cell Maturation through NF-κB Pathway. Cell Prolif, doi: 10.1111/cpr.12358.
Lu G., Wong M.S., Xiong M.Z.Q., Leung C.K., Su X.W., Zhou J.Y., Poon W.S., Zheng V.Z.Y., Chan W.Y., & Wong G.K.C. (2017). Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. J Am Heart Assoc, 6:4.
Wang W.M., Lu G.^#, Su X.W., Lyu H., & Poon W.S. (2017). MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway. Front Cell Neurosci, 11:96.
Liu P.C., Lu G.^#, Deng. Y., Wang C.D., Su X.W., Zhou J.Y., Chan T.M., Hu X., & Poon W.S. (2017). Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy. PLoS ONE, 12(1):e0171157.
Liu Y., Ao L.J., Lu G.^*, Leong E., Liu Q., Wang X.H., Zhu X.L., Sun T.F., Fei Z., Jiu T., Hu X., & Poon W.S. (2013). Quantitative gait analysis of long-term locomotion deficits in classical unilateral striatal intracerebral hemorrhage rat model. Behav Brain Res, 257: 166-77.
Wang X.H., Lu G.^#, Hu X., Tsang K.S., Kwong W.H., Wu F.X., Meng H.W., Jiang S., Liu S.W., Ng H.K., & Poon W.S. (2012). Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson’s disease. BMC Neurosci, 13:142.
Zhang J.F., Fu W.M., He M.L., Wang H., Wang W.M., Yu S.C., Bian X.W., Zhou J., Lin M.C., Lu G.^*, & Poon W.S., Kung H.F. (2011). MiRNA-637 Maintains the Balance between Adipocyte and Osteoblast by Directly Targeting Osterix. Molecular Biology of the Cell,22 (21):3955-3961.
Li Q., Lu G.^#, Kwong W.H., Choi H.L., Zeng X.F., Li Z., Yew D.T., & Poon W.S. (2011). Programmed Neuronal Cell Death Induced by HIV-1 Tat and Methamphetamine. Microscopy Research and Technique, 74(12):1139-44.
Li Q., Lu G., Antonio G.E., Mak Y.T., Rudd J.A., Fan M., & Yew D.T. (2007). The usefulness of the spontaneously hypertensive rat to model attention-deficit / hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Neurochem Int, 50(6):848-57.
Lu G., Wu Y., Mak Y.T., Wai S.M., Feng Z.T., Rudd J.A., & Yew D.T. (2006). Molecular evidence of the neuroprotective effect of Ginkgo biloba (EGb761) using bax/bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8. Brain Res, 1090(1):23-28.
Poon W.S., Lu G., Tsang K.S., Zhu X.L., Chen G., & Ng H.K. (2006) Migration of bone marrow stem cells in ischaemic brain. Acta Neurochir Suppl, 99:123-124.
Lu G., Wai S.M., Poon W.S., & Yew D.T. (2005). Ki67 and doublecortin positive cells in human prefrontal cortices of normal aging and vascular dementia. Microscopy Research and Technique, 68(5):255-257.
Lu G., Mak Y.T., Wai S.M., Kwong W.H., Fang M., James A., Randall D., & Yew D.T. (2005). Hypoxia-induced differential apoptosis in the central nervous system of the sturgeon. Microscopy Research and Technique, 68(5):258-63.
Lu G., Kwong W.H., Li Q., Wang X., Feng Z., & Yew D.T. (2005). bcl2, bax, and nestin in the brains of patients with neurodegeneration and those of normal aging. J Mol Neurosci, 27(2):167-174.* Co-corresponding author
^# Co-first author

研究資助

Innovation and Technology Support Programme [PI; 01-Nov-2019 to 31-Oct-2021]: “Study of circulating miRNAs in prediction of stroke risk after transient ischemic attack” (HK$1,627,940).
Innovation and Technology Support Programme [PI; 01-Mar-2018 to 30-Sep-2020]: “Enrichment of Extracellular Vesicles Secreted by Human-induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Ischemic Stroke” (HK$1,299,500).
CUHK One-off Funding for Hong Kong Branch of Chinese National Engineering Research Centers [PI; 01-Jul-2015 to 30-Jun-2017]: “Center for Assisted Reproductive Technology and Reproductive Genetics” (HK$330,000).
Innovation and Technology Support Programme [PI; 01-Jul-2013 to 30-Jun-2015]: “Development of TRAIL-secreting Umbilical Cord Mesenchymal Stem Cells for Glioblastoma Treatment” (HK$990,000).
Ministry of Science and Technology – National High-Tech Research and Development Program of China [Co-PI; 2012 to 2015]: “R&D and large – scale manipulation of cell products for immunotherapy” (CND2,760,000).