研究項目 - 生物醫學學院

徐國榮教授及曹沁教授領導的研究發現常用的軟件工具產生相互衝突且過於樂觀的 AUPRC 值

The area under the precision-recall curve (AUPRC) is a valuable metric for quantifying classification performance, particularly in situations with imbalanced classes like cancer diagnosis and cell type annotation.

生物醫學學院高波教授領導的合作研究揭示先天性脊柱側彎的發病原因

Congenital Scoliosis (CS) is the most common congenital spinal disorder caused by congenital vertebral malformations (CVMs), affecting approximately 0.5 to 1 in 1,000 live births. CS is influenced by genetic and environmental factors and exhibits diverse clinical presentations.

研究揭示脂肪組織褐變的性別差異機制

Beige fat is gaining therapeutic interest due to its potential in combating obesity and other diseases. Starting from single clone analysis, Zhao et al. discovered that androgen receptor (AR) turns out to be a highly potent transcription factor in suppression of PRDM16, the key molecular switch in beige fat.

揭示青少年特發性脊柱側彎的發病原因

Adolescent Idiopathic Scoliosis (AIS) is the most common paediatric skeletal disease affecting more than 20 million adolescents worldwide. Despite its high prevalence and considerable physical and psychological impacts on patients and their families, the etiopathogenesis of AIS is still elusive and controversial. Preventive treatment and pharmacological intervention remain unavailable for AIS. Treatment is limited to managing spinal deformity post-onset, through bracing and/or invasive surgery.

鄭詩樂教授領導的研究發現新型納米免疫療法對抗肝癌

趙暉教授領導的研究發現母源表觀遺傳修飾調控生殖隔離

蔣曉華教授及霍建霖教授領導之協作研究揭示精子趨化性缺陷為不明原因不孕症潛在病因

張凱鴻教授領導的合作研究發現Omicron變異株在人腦類器官中複製能力增強

夏銀教授領導的研究發現YAP調控腎髒內水重吸收

馮波教授開發肝臟介導的基因編輯治療

岑美霞教授領導的研究破譯Shh信號通路介導的耳蝸毛細胞分化機製

姚曉強教授領導的團隊發現一種調控癌细胞肌動蛋白的新因子

陳偉儀教授團隊揭示心肌生成的獨特表觀遺傳機制

大分子擁擠作用下具有功能性的3D微血管網絡芯片

Application of the biophysical principle of macromolecular crowding (MMC) to microvascular networks in microfluidic devices provides a reliable, flexible and versatile approach to stabilize engineered human microvessels under simulated physiological conditions. MMC promoted the enrichment of cellular junctions and basement membrane components, while reducing cellular contractility.

口服負載生物活性玻璃的水凝膠微球治療炎性腸病

New therapy for inflammatory bowel disease (IBD) is needed due to primary drug failure or loss of response to drugs for patients suffering from the disease. The recent findings from the collaborative work led by Prof. Hon Fai Chan demonstrated that bioactive glass (BG), a clinically-approved bone graft material with immunomodulatory property, holds potential to treat IBD when taken orally.

鄭詩樂教授研究團隊發現肥胖引起的免疫紊亂可促進肝癌

使用圖神經網絡捕獲生物對象的複雜關係

惠曉艷教授領導之研究揭示肝臟和脂肪組織之間的對話

以胚胎幹細胞研究兒童腫瘤

陳偉儀教授研究團隊發現Werner綜合症中的骨發育缺陷