陈良教授 – 生物醫學學院

陈良教授

Professor

B.Sc., Ph.D.

39436841

franky-chan@cuhk.edu.hk

香港中文大学第39区罗桂祥综合生物医学大楼519A室

Publons

ORCID

个人简介

Prof. CHAN Leung Franky (陈良) obtained his Ph.D. degree from The University of Hong Kong in 1989 and received his postdoctoral training in McGill University (Montreal, Canada) thereafter. He joined The Chinese University of Hong Kong as a lecturer in the Department of Anatomy in 1992 and is presently a full professor at the School of Biomedical Sciences. Prof. Chan has published more than 120 original research papers, including Cancer Research, Oncogene, Journal of Pathology, Journal of Clinical Endocrinology and Metabolism, Endocrinology and PNAS. Chan’s primary research focus is on the hormonal carcinogenesis of prostate cancer. His current research topics include: (1) orphan nuclear receptors-mediated signaling pathways, (2) cancer stem cells in prostate cancer, (3) epithelial mesenchymal transition in metastasis, (4) molecular targeted therapy and immunotherapy of prostate cancer, and (5) signaling pathways involved in castration-resistant and neuroendocrine prostate cancer.

Research Interests

Hormonal carcinogenesis and cancer biology of prostate gland.
Orphan nuclear receptors-mediated signaling pathways in prostate gland development and prostate cancer.
Tumor microenvironment, epithelial-mesenchymal-transition and hypoxia in prostate cancer.
Molecular targeted therapy and immunotherapy of prostate cancer.
Cancer stem cells in prostate cancer.

Selected Publications

Gao, W., Wang, Y., Yu, S., Wang, W., Ma, T., Chan, A.M., Chiu, P. K., Ng, C.F., Wu, D. & Chan, F.L. (2022). Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells. Stem Cell Research & Therapy 13(1):188.
Zhou, J., Wang, Y., Wu, D., Wang, S., Chen, Z., Xiang, S. & Chan, F.L. (2021). Orphan nuclear receptors as regulators of intratumoral androgen biosynthesis in castration-resistant prostate cancer. Oncogene 40(15): 2625-2634.
Wang, Y., Gao, W., Li, Y., Chow, S.T., Xie, W., Zhang, X., Zhou, J. & Chan, F.L. (2021). Interplay between orphan nuclear receptors and androgen receptor-dependent or -independent growth signalings in prostate cancer. Molecular Aspects of Medicine 78, 100921.
Xu ,Z., Ma, T., Zhou, J., Gao, W., Li, Y., Yu, S., Wang, Y. & Chan, F.L. (2020). Nuclear receptor ERR contributes to castration-resistant growth of prostate cancer via its regulation of intratumoral androgen biosynthesis. Theranostics 2020, 10(9): 4201-4216.
Wang, Z., Li, Y., Wang, Y., Wu, D., Lau, A.H.Y., Zhao, P., Zou, C., Dai, Y. & Chan, F.L. (2020). Targeting prostate cancer stem-like cells by an immunotherapeutic platform based on immunogenic peptide-sensitized dendritic cells-cytokine-induced killer cells. Stem Cell Research & Therapy 11, 123.
Wang, Z., Li, Y., Wu, D., Yu, S., Wang, Y. & Chan, F.L. (2020). Nuclear receptor HNF4 performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence. Oncogene 39(7), 1572-1589.
Guo, Z., Wang, Y., Xiang, S., Wang, S. & Chan, F.L. (2019). Chromogranin A is a predictor of prognosis in patients with prostate cancer: A systemic review and meta-analysis. Cancer Management and Research 11, 2747-2758.
Gao, W., Wu, D., Wang, Y., Wang, Z., Zou, C., Dai, Y., Ng, C.F., Teoh, J.Y.C., & Chan, F.L. (2018). Development of a novel and economical agar-based non-adherent three-dimensional culture method for enrichment of cancer stem-like cells. Stem Cell Research & Therapy, 9, 243.
Xu, Z., Wang, Y., Xiao, Z.G., Zou, C., Zhang, X., Wang, Z., Wu, D., Yu, S., & Chan, F.L. (2018). Nuclear receptor ERR and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2:ERG fusion gene in prostate cancer. Oncogene, 37(48), 6259-6274.
Jia, L., Wu, D., Wang, Y., You, W., Wang, Z., Xiao, L., Cai, G., Xu, Z., Zou, C., Wang, F., Teoh, J.Y.C., Ng, C.F., Yu, S., & Chan, F.L. (2018). Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription. Oncogene, 37(25), 334-3355.
Xiao, L., Wang, Y., Xu, K., Hu, H., Xu, Z., Wu, D., Wang, Z., You, W., Ng, C.F., Yu, S., & Chan, F.L. (2018). Nuclear receptor LRH-1 functions to promote castration-resistant growth of prostate cancer via its promotion of intratumoral androgen biosynthesis. Cancer Research, 78(9), 2205-2218.
Wang, Z., Wu, D., Ng, C.F., Teoh, J.Y.C., Yu, S., Wang, Y., & Chan, F.L. (2018). Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer. Endocrine-Related Cancer, 25(1), 35-50.
Cai, G., Wu, D., Wang, Z., Xu, Z., Wong, K.B., Ng, C.F., Chan, F.L., & Yu, S. (2017). Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization. Oncogene, 36(4), 546-558.
Wu, D., Cheung, A., Wang, Y., Yu, S., & Chan, F.L. (2016). The emerging roles of orphan nuclear receptors in prostate cancer. Biochimica et Biophysica Acta Reviews on Cancer, 1866(1), 23-36.
Wu, D., Yu, S., Jia, L., Zou, C., Xu, Z., Xiao, L., Wong, K.B., Ng, C.F., & Chan, F.L. (2015). Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of CDKN1A (p21WAF1/CIP1) and SIRT1 genes. The Journal of Pathology, 236(1), 103-115.
Sailland, J., Tribollet, V., Forcet, C., Billon, C., Barenton, B., Carnesecchi, J., Gauthier, K.C., Yu, S., Giguère, V., Chan, F.L., & Vanacker, J.M. (2014). Estrogen-related receptor α decreases RHOA stability to induce oriented cell migration. Proceedings of the National Academy of Sciences of the United States of America, 111(42), 15108-15113.
Yu, S., Xu, Z., Zou, C., Wu, D., Wang, Y., Yao, X., Ng, C.F., & Chan, F.L. (2014). Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2-independent and RACK1-mediated mechanism of HIF-1α stabilization. The Journal of Pathology, 234(4), 514-525.
Zou, C., Yu, S., Xu, Z., Wu, D., Ng, C.F., Yao, X., Yew, D.T., Vanacker, J.M., & Chan, F.L. (2014). ERRα augments HIF-1 signaling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells. The Journal of Pathology, 233(1), 61-73.
Yu, S., Lin, Jia L., Zhang, Y., Wu, D., Xu, Z., Ng, C.F., To, K.K., Huang, Y., & Chan, F.L. (2013). Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation. Cancer Letters, 328(1), 83-94.
Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J., & Yao, X. (2012). Transient receptor potential channel TRPC5 is essential for p-glycoprotein induction in drug-resistant cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16282-16287.
Luk, S.U., Lee, T.K., Liu, J., Lee, D.T., Chiu, Y.T., Ma, S., Ng, I.O., Wong, Y.C., Chan, F.L., & Ling, M.T. (2011). Chemoprevention effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One, 6(5), e19804.
Yu, S., Zhang, Y., Yuen, M.T., Zou, C., Danielpour, D., & Chan, F.L. (2011). 17-Beta-estradiol induces neoplastic transformation in prostatic epithelial cells. Cancer Letters, 304(1), 8-20.
Yu, S., Wang, M.W., Yao, X., & Chan, F.L. (2009). Establishment of a novel immortalized human prostatic epithelial cell line stably expressing androgen receptor and its application for the functional screening of androgen receptor modulators. Biochemical and Biophysical Research Communications, 382(4), 756-761.
Chu, J.H., Yu, S., Hayward, S.W., & Chan, F.L. (2009). Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer. Prostate, 69(4), 428-442.
Yu, S., Wong, Y.C., Wang, X., Ling, M.T., Ng, C.F., Chen, S., & Chan, F.L. (2008). Orphan nuclear receptor estrogen-related receptor-β suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer. Oncogene, 27(23), 3313-3328.
Yu, S., Wang, X., Ng, C.F., Chen, S., & Chan, F.L. (2007). ERRγ suppresses cell proliferation and tumor growth of androgen-sensitive and -insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Research, 67(10), 4904-4914.
Lui, K., Huang, Y., Choi, H.L., Yu, S., Wong, K.B., Chen, S., & Chan, F.L. (2006). Molecular cloning and functional study of rat estrogen receptor-related receptor γ in rat prostatic cells. Prostate, 66(15), 1600-1619.
Yuen, M.T., Leung, L.K., Wang, J., Wong, Y.C., & Chan, F.L. (2005). Enhanced induction of prostatic dysplasia and carcinoma in Noble rat model by combination of neonatal estrogen exposure and hormonal treatments at adulthood. International Journal of Oncology, 27(6), 1685-1695.
Chua, C.W., Lee, D.T., Ling, M.T., Zhou, C., Man, K., Ho, J., Chan, F.L., Wang, X., & Wong, Y.C. (2005). FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer. International Journal of Cancer, 117, 1039-1048.
Kwok, W.K., Ling M.T., Lee, T.W., Lau, T.C., Zhou, C., Zhang, X., Chua C.W., Chan, K.W., Chan, F.L., Glackin, C., Wong, Y.C., & Wang, X. (2005). Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Research, 65(12), 5153-5162.
Cheung, C.P., Yu, S., Wong K.B., Chan, L.W., Lai, F.M., Wang, X., Suetsugi, M., Chen, S., & Chan, F.L. (2005). Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. The Journal of Clincial Endocrinology and Metabolism, 90(3), 1830-1844.
Duan, W., Gabril, M.Y., Moussa, M., Chan, F.L., Sakai, H., Fong, G., & Xuan, J.W. (2005). Knockin of SV40 Tag oncogene in a mouse adencarcinoma of the prostate model demonstrates advantageous features over the transgenic model. Oncogene, 24(9), 1510-1524.

Grants

RGC – General Research Fund [PI:01-Jan-2023 to 31-Dec-2025]: “Elucidating the role of transcription factor MYT1 in neuroendocrine transdifferentiation of prostate cancer” (HK$1,180,218).
Health and Medical Research Fund [PI: 01-Jan-2022 to 31-Dec-2024]: “Functional characterization and therapeutic implication of nuclear receptor ERRalpha in mitochondrial metabolism and remodeling in prostate cancer” (HK$1,499,940).
National Natural Science Foundation of China (NSFC) – Hong Kong Research Grants Council (RGC) Joint Research Scheme [PI: 01-Jan-2021 to 31-Dem-2024]: “Elucidating the functional role of transcription factor SIX2 and its targeting in neuroendocrine prostate cancer” (HK$1,171,828).
Health and Medical Research Fund [PI; 08-May-19]: “Establishment and Characterization of Nuclear Receptor NURR1 as a Potential Therapeutic Target for Castration-resistant Prostate Cancer” (HK$1,497,300)
RGC – General Research Fund [PI; 01-Jan-19]: “Elucidating the roles of nuclear receptor TLX in regulation of cancer stem cells and metastasis in prostate cancer” (HK$971,990).
RGC – General Research Fund [PI; 01-Jan-18 to 31-Dec-20]: “Elucidating the role of endothelial nitric oxide synthase (eNOS) in prostate cancer” (HK$1,018,301).
RGC – General Research Fund [PI; 01-Jan-17 to 31-Dec-19]: “Elucidating the Role of Estrogen-related Receptor Alpha in Growth Regulation of Prostate Cancer Stem Cells” (HK$1,000,103).
Innovation & Technology Commission-Innovation and Technology Support Programme [PI; 01-Oct-16 to 30-Sep-18]: “Establishment of a T-cell Therapeutic Platform Targeting Prostate Cancer Stem Cells” (HK$983,468).
Shenzhen Noah Ark Biotech Co. Ltd. [PI; 01-Oct-16 to 30-Sep-18]: “Establishment of a T-cell Therapeutic Platform Targeting Prostate Cancer Stem Cells” (HK$110,000).
Health and Medical Research Fund [PI; 01-Apr-15 to 31-Mar-17]: “A Functional Study of Nuclear Receptor LRH-1 and its Targeting in Prostate Cancer” (HK$999,040).
RGC – General Research Fund [PI; 01-Jan-15 to 30-Jun-18]: “Elucidating the Role of Estrogen-related Receptor Alpha in Castration-resistant Prostate Cancer” (HK$889,354).