研究项目 - 生物醫學學院

徐国荣教授及曹沁教授领导的研究发现常用的软件工具产生相互冲突且过于乐观的 AUPRC 值

The area under the precision-recall curve (AUPRC) is a valuable metric for quantifying classification performance, particularly in situations with imbalanced classes like cancer diagnosis and cell type annotation.

生物医学学院高波教授领导的合作研究揭示先天性脊柱侧弯的发病原因

Congenital Scoliosis (CS) is the most common congenital spinal disorder caused by congenital vertebral malformations (CVMs), affecting approximately 0.5 to 1 in 1,000 live births. CS is influenced by genetic and environmental factors and exhibits diverse clinical presentations.

研究揭示脂肪组织褐变的性别差异机制

Beige fat is gaining therapeutic interest due to its potential in combating obesity and other diseases. Starting from single clone analysis, Zhao et al. discovered that androgen receptor (AR) turns out to be a highly potent transcription factor in suppression of PRDM16, the key molecular switch in beige fat.

揭示青少年特发性嵴柱侧弯的发病原因

Adolescent Idiopathic Scoliosis (AIS) is the most common paediatric skeletal disease affecting more than 20 million adolescents worldwide. Despite its high prevalence and considerable physical and psychological impacts on patients and their families, the etiopathogenesis of AIS is still elusive and controversial. Preventive treatment and pharmacological intervention remain unavailable for AIS. Treatment is limited to managing spinal deformity post-onset, through bracing and/or invasive surgery.

郑诗乐教授领导的研究发现新型纳米免疫疗法对抗肝癌

(EN) Research led by Prof. Zhao Hui discovers maternally-defined epigenetic modification regulates reproductive isolation

赵晖教授领导的研究发现母源表观遗传修饰调控生殖隔离

蒋晓华教授及霍建霖教授领导之协作研究揭示精子趋化性缺陷为不明原因不孕症潜在病因

张凯鸿教授领导的合作研究发现Omicron变异株在人脑类器官中复制能力增强

夏银教授领导的研究发现YAP调控肾脏内水重吸收

冯波教授开发肝脏介导的基因编辑治疗

(EN) Prof. Feng Bo develops liver-specific knock-in for safe gene therapy

岑美霞教授领导的研究破译Shh信号通路介导的耳蜗毛细胞分化机制

姚晓强教授领导的团队发现一种调控癌细胞肌动蛋白的新因子

陈伟仪教授团队揭示心肌生成的独特表观遗传机制

大分子拥挤作用下具有功能性的3D微血管网络芯片

Application of the biophysical principle of macromolecular crowding (MMC) to microvascular networks in microfluidic devices provides a reliable, flexible and versatile approach to stabilize engineered human microvessels under simulated physiological conditions. MMC promoted the enrichment of cellular junctions and basement membrane components, while reducing cellular contractility.

口服负载生物活性玻璃的水凝胶微球治疗炎性肠病

New therapy for inflammatory bowel disease (IBD) is needed due to primary drug failure or loss of response to drugs for patients suffering from the disease. The recent findings from the collaborative work led by Prof. Hon Fai Chan demonstrated that bioactive glass (BG), a clinically-approved bone graft material with immunomodulatory property, holds potential to treat IBD when taken orally.

郑诗乐教授研究团队发现肥胖引起的免疫紊乱可促进肝癌

使用图神经网络捕获生物对象的复杂关系

惠晓艳教授领导之研究揭示肝脏和脂肪组织之间的对话

以胚胎干细胞研究儿童肿瘤

陈伟仪教授研究团队发现Werner综合症中的骨发育缺陷