This study led by Prof. Alfred Cheng Sze-lok uncovered the pivotal effect of PD-L1 nano-trap against M2 macrophages in the tumor-surrounding fibrosis, creating a CD8+T cell-inflamed tumor microenvironment for cancer eradication. The predominant PD-L1 expression in M2 macrophages of HCC mouse models and patient cohorts further supports the translation of this effective nano-immunotherapy modality for patients with HCC and other deadly cancers with dense stroma deposition around lesions.

The findings have been published in Molecular Therapy: https://www.sciencedirect.com/science/article/pii/S1525001622005664?via%3Dihub.
#CUHK #CUHKSBS #biomedicalsciences #research #MolecularTherapy

Article post link: https://www.sciencedirect.com/science/article/pii/S1525001622005664?via%3Dihub