陈汉辉教授 – 生物醫學學院

陈汉辉教授

Associate Professor

组织工程与再生医学研究所副教授

39433032

honfaichan@cuhk.edu.hk

Room 423A, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Publons

ORCID

Prof. CHAN Hon Fai (陈汉辉) is an Associate Professor at the Institute for Tissue Engineering and Regenerative Medicine and the School of Biomedical Sciences at The Chinese University of Hong Kong (CUHK). He received his Bachelor degree from the University of Hong Kong (2010), before pursuing his Ph.D. degree at Duke University with the support of the Sir Edward Youde Memorial Fellowships for Overseas Studies. During 2015-2017, he worked as a postdoctoral researcher at Columbia University and Massachusetts Institute of Technology before joining CUHK in 2018. Prof. Chan’s research mainly focuses on advancing biofabrication approach and biomaterial design for stem cell tissue engineering and regenerative medicine, as well as understanding how microenvironmental cues influence stem cell proliferation and differentiation.

Research Interests

Biofabrication technologies (e.g. microfluidics, 3D bioprinting) for stem cell tissue engineering.
Biomaterial for tissue engineering and regenerative medicine.
Tissue/organ-on-a-chip.

Selected Publications

Deng, S., Zhao, X., Kou, Z., Zhu, Y., Zhang, X., Chan, H.F.# (2023) Effect of Valproic Acid on Promoting the Differentiation of Human Embryonic Stem Cells Into Cholangiocyte-Like Cells. Stem Cells Translational Medicine.
Zhu Y., Wang, Y., Xia, G., Zhang, X., Deng, S., Zhao, X., Xu, Y., Chang, C., Tao, Y., Li, M., Li, H., Huang, X., Chan, H.F.# (2023) Oral Delivery of Bioactive Glass‐Loaded Core–Shell Hydrogel Microspheres for Effective Treatment of Inflammatory Bowel Disease. Advanced Science, 10 (18), 2207418
Deng, S., Zhao, X., Zhu, Y., Tang, N., Wang, R., Zhang, X., Qu, F., Ho, Y., Lee, W.Y., Chen, J., Li, M., Tao, Y., Chan, H.F.# (2022) Efficient Hepatic Differentiation of Hydrogel Microsphere-Encapsulated Human Pluripotent Stem Cells for Engineering Prevascularized Liver Tissue. Biofabrication, 15 (1), 015016.
Deng, S., Zhu, Y., Zhao, X., Chen, J., Tuan, R.S., Chan, H.F.# (2021) Efficient Fabrication of Monodisperse Hepatocyte Spheroids and Encapsulation in Hybrid Hydrogel with Controllable Extracellular Matrix Effect. Biofabrication, 14 (1), 015002.
Zhu, Y., Ma, Z., Kong, L., He, Y., Chan, H.F.#, & Li, H.# (2020). Modulation of Macrophages by Bioactive Glass/Sodium Alginate Hydrogel is Crucial in Skin Regeneration Enhancement. Biomaterials, 256.
Zhao, X., Zhu, Y., Laslett, A., Chan, H.F.# (2020). Hepatic Differentiation of Stem Cells in 2D and 3D Biomaterial Systems. Bioengineering, 7 (2), 47.
Liu, X., Steiger, C., Lin, S., Parada, G.A., Liu, J., Chan, H.F., Yuk, H., Phan, N.V., Collins, J., Tamang, S., Traverso, G., & Zhao, X.# (2019). Ingestible Hydrogel Device. Nature Communications, 10(1), 493.
Chan, H.F., Zhao, R., Parada, G. A., Meng, H., Leong, K. W., Griffith, L. G., & Zhao, X.# (2018). Folding Artificial Mucosa with Cell-Laden Hydrogels Guided by Mechanics Models. Proceedings Of The National Academy Of Sciences, 115 (29), 7503-7508.
Chan, H.F., Zhang, Y., & Leong, K.W. (2016). Efficient One-Step Production of Microencapsulated Hepatocyte Spheroids with Enhanced Functions. Small, 12(20), 2720-30.
Hong, S., Sycks, D., Chan, H.F., Lin, S., Lopez, G.P., Guilak, F., Leong, K.W., & Zhao, X.# (2015). 3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures. Advanced Materials, 27(27), 4035-40.

# Corresponding author

Grants

Guangdong-Hong Kong Technology Cooperation Funding Scheme (TCFS) [PI; 30-Jun-22 to 29-Jun-24]: “Clinical application of retinal organoid-on-a-chip for investigating the disease mechanism of and treatment for retinal degenerative diseases” (HK$667,450).
Health and Medical Research Fund (HMRF) [PI; 01-Feb-22 to 31-Jan-25]: “Dual release of desferrioxamine and bioglass via an injectable hydrogel for treatment of pressure ulcer in diabetes mellitus” (HK$1,213,780).
National Natural Science Foundation of China/RGC Joint Research Scheme (NSFC/RGC) [PI; 01-Jan-21 to 31-Dec-24]: “Biomimetic Platform of Perfusable Organoid-chip for Studying the Molecular Pathogenesis of Retinitis Pigmentosa” (HK$1,156,567).
National Key Research and Development Program of China 2019 [Co-PI; 01-Dec-19 to 30-Nov-23]: “Smart biomaterials for directing stem cell differentiation in 3D for constructing bioartificial liver” (RMB$5,000,000).
National Key Research and Development Program of China 2018 [Co-PI; 01-Jul-19 to 30-Jun-24]: “Engineering microbial chassis for synthetic biology applications” (RMB$4,890,000).
RGC Early Career Scheme [PI; 01-Jan-20 to 31-Dec-23]: “Development of a microfluidic platform for biofabricating 3D spheroid entrapped in combinatorial microenvironment for optimized hepatocyte culture” (HK$343,034).
Shun Hing Institute of Advanced Engineering Project Fund [PI; 01-Jul-19 to 30-Jun-21]: “Development of a bilayer folded scaffold for intestinal tissue engineering” (HK$800,000).