陈伟仪教授 – 生物醫學學院

陈伟仪教授

Li Ka Shing Professor of Biomedical Sciences

B.Sc., Ph.D.

39431383

chanwy@cuhk.edu.hk

Room 123A, 1/F., Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Publons

ORCID

个人简介

Chan Wai-yee (陳偉儀) obtained his BSc (Hon. 1st Class) in Chemistry from The Chinese University of Hong Kong in 1974 and PhD in Biochemistry from the University of Florida, Gainesville, Florida, USA in 1977. He served as tenured Assistant to Associate Professor at the Department of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA from 1979-1989, and tenured Professor, Department of Pediatrics and Department of Biochemistry, Cell & Molecular Biology at Georgetown University Medical Center, Washington, DC, USA from 1989-2009. He was jointly appointed at the Eunice Kennedy Shriver National of Child Health and Human Development (NICHD), National Institutes of Health (NIH), USA in 2001, and was later appointed as Head and Principal Investigator of the Section on Developmental Genomics and co-founded the Laboratory of Clinical Genomics, NICHD. In 2009, he established the School of Biomedical Sciences, Faculty of Medicine, CUHK, and served as the Founding Director and Chair Professor of Biomedical Sciences. He served as Master of CW Chu College from 2017-2021. He was appointed Pro-Vice-Chancellor (Strategic Developments)/ Vice President of CUHK in 2018 and Li Ka Shing Professor of Biomedical Sciences in 2020. He is also the Director of Institute for Tissue Engineering and Regenerative Medicine (iTERM). He has served as President of the Association of Chinese Geneticists in America, a Member of the Development Committee of the Society for the Study of Reproduction in the USA, and the immediate past President of Hong Kong Institution of Science. Besides being a Council Member of the Shaw Prize Foundation, he also serves as Member of the Hospital Authority Board, Chair of the Hospital Governing Committee of North District Hospital, Member of the Research Grant Council, Member of the Hong Kong Genome Institute Board of Directors, and a Specialist for the Hong Kong Council for Accreditation of Academic and Vocational Qualifications. He also serves in the Scientific Advisory Board of Hope for Rare Foundation, Shanghai, China. He received a number of awards including the Merrick Award for Outstanding Biomedical Research and the Presidential Award from the Association of Chinese Geneticists in America, USA.

Research Interests

Functional genomics and epigenetic regulation of germ cell and gonad development in health and diseases.
Functional genomics of developing male gonad.
Molecular genetics of human endocrine disorders.
Non-coding RNA, antisense transcript, and microRNA in normal and abnormal development.
Genetics and genomics of fetal development.

Selected Publications

RGC/NSFC Joint Grant Scheme 2022/2023. Reference Code: N_CUHK 428/22; CU Project Code: 2900424[PI; 01-Jan-23 to 31-Dec-26]: “Study the roles of mitochondrial DNA methylation in regulating nucleoid phase separation and transcription modulation.” (HK$1,125,254).
CUHK Direct Grant for Research 2022/2023. Reference Code: 2022.082. [PI; 30-Jun-23 to 29-Jun-24]: “WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome.” (HK$50,000).
广东省基础与应用基础研究重大项目(基石项目). 广东省科学技术厅, Project Code: 8326203. [PI; 01-Mar-23 to 31-Feb-28]: “能量代谢调控细胞全能性与多能性转变的机制与转化研究” (RMB500,000).
ITF – MHKJFS 2023 Program. Reference: MHP/005/23. [PI; 01-Mar-23 to 28-Feb-26]: ” Establishment of mitochondrial disease model and drug screening by using induced pluripotent stem cells.” (HK$1,115,200).
: 粤港干细胞与再生医学联合实验室. 广东省科学技术厅粤港澳大湾区国际科技创新中心建设[PI; 01-Apr-23 to 31-Mar-26]: (RMB600,000).
ITC, General Support Program. Reference Code: GSP/003/24.[PI; 1-Feb-24 to 1-Jul-24]: ” Global Conference on Climate Change.” (HK$2,026,880).

Huang T, Wu X, Wang S, Bao Z, Wan Y, Wang Z, Li M, Yu X, Lv Y, Liu Z, Chen X, Chan WY, Gao F, Lu G, Chen Z, Liu H. SPIDR is required for homologous recombination during mammalian meiosis. Nucleic Acid Res. 51(8), 3855-3868, Feb 2023. (IF:19.16)
Xu K, Su X, Fang K, Lv Y, Huang L, Li M, Wang Z, Yin Y, Muhammad T, Liu S, Chen X, Jiang J, Li J, Chan WY, Ma J, Lu Gang, Chen ZJ, Liu H. The slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice. eLife, 12, e83129, 2023 March 21, (Published online https://doi.org/10.7554/eLife.83129) (IF: 8.713)
Muhammad T, Wan Y, Lv Y, Li H, Chan WY, Lu G, Chen ZJ, Liu H. Maternal Obesity: a potential disruptor of female fertility and current 2 interventions to reduce associated risks. Obesity Reviews, 24(1), e13603, 2023 July 14, DOI: 10.1111/obr.13603; https://doi.org/10.1111/obr.13603 (IF:10.867; Ranking 9/148).
Du Y, Li S, Zhai J, Chu W, Geng X, Wang D, Jiao L, Lu G, Chan WY, Sun K, Sun Y, Chen ZJ. Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling. Biofilms and Microbiomes. 2023 July 8; 9(1):47. doi: 10.1038/s41522-023-00415-2. (IF: 8.462)
He X, Mu W, Wang Z, Xu K, Yin Y, Lu G, Chan WY, Liu H, Lv Y, Liu S. Deficiency of the Tmem232 gene causes male infertility with morphological abnormalities of the sperm flagellum in mice. Cells, 2023, Jun 13; 12(12):1614. https://doi.org/10.3390/cells12121614 (IF: 7.666)
Lu G, Su X, Wang LH, Leung CK, Zhou J, Xiong Z, Wang W, Liu H, Chan WY. Neuroprotective effects of human-induced pluripotent stem cell-derived mesenchymal stem cell extracellular vesicles in ischemic stroke models. Biomedicines, 2023, September 11, 2550. https://doi.org/10.3390/biomedicines11092550 (IF: 4.757).
Wan Y, Yang S, Li T, Cai Y, Wu X, Zhang M, Muhammad T, Huang T, Lv Y, Chan WY, Lu G, Li J. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Research, 2023 Nov 27;51(21):11652-11667. doi: 10.1093/nar/gkad919. (IF: 19.16)
Wang C, Liu Z, Zeng Y, Zhou L, Long Q, Hassan IU, Zhang Y, Qi XF, Cao DQ, Mao B, Lu G, Sun J, Yao YG, Deng Y, Zhao Q, Feng B, Zhou Q, Chan WY, Zhao H. ZSWIM4 regulates embryonic patterning and BMP signaling by promoting nuclear Smad1 degradation. EMBO Reports, 2024 Feb; 25(2):646-671. doi: 10.1038/s44319-023-00046-w. Epub 2024 Jan 2. (IF: 13.783)
Yang L, Ruan Z, Lin X, Wang H, Xin Y, Tang H, Zhou Y, Wu Yi, Wang J, Qin D, Lu G, Loomes KM, Chan WY, Liu X. NAD⁺ dependent UPR^mt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nature Communications, 2024 Jan 16;15(1):546. doi: 10.1038/s41467-024-44808-z. (IF: 17.69)
Tian Y, Lautrup S, Law WN, Dinh ND, Fang EF, Chan WY. WRN loss accelerates abnormal adipocyte metabolism in Werner Syndrome. Cell & Biosciences, Jan 6, 2024, DOI:10.1186/s13578-023-01183-4. (IF: 9.597)
Suen H-C, Ou F, Miu KK, Wang Z, Chan WY, Liao J. The single-cell chromatin landscape in gonadal cell lineage specification and sex fate determination. BMC Genomics, April 2024 (IF: 4.4)
Hu Z, Yang L, Zhang M, Tang H, Huang Y, Su Y, Ding Y, Li C, Wang M, Zhou Y, Zhang Q, Guo L, Wu Y, Wang Q, Liu N, Kang H, Wu Y, Yao D, Li Y, Ruan Z, Wang H, Bao F, Liu G, Wang J, Wang Y, Wang W, Lu G, Qin D, Pei D, Chan WY, Liu X. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metabolism. May 3, 2024, https://doi.org/10.1016/j.cmet.2024.04.012 (IF: 29.0)

Grants

Li Ka Shing (Canada) Foundation [PI; 22-Jul-19]: “Acquisition of the MARS Preclinical Spectral CT System that will facilitate the research projects in iTERM” (HK$3,699,300).
Health and Medical Research Fund [PI; 24-May-19]: “A Star Strand miRNA as a Versatile Biomarker and Therapeutic for Diabetic Liver Steatosis” (HK$1,220,800).
RGC – General Research Fund [PI; 01-Jan-19]: “Elucidating the indispensable role of miR-10 family in ovarian follicular development” (HK$798,968).
Shandong University [PI; 01-Sep-18 to 31-Aug-21]: “SDU-CUHK Seed Fund for International Research Collaboration” (RMB1,800,000).
Guangdong Hospital of Traditional Chinese Medicine (GD-TCM) Joint Lab [PI; 01-Mar-18]: “Collaboration between CUHK and the Guangdong Hospital of Traditional Chinese Medicine (TCM) to establish the “Translational Collaborative Innovation Programme”” (HK$10,000,000).
CUHK – Shanghai Jiao Tong University (SJTU) Joint Research Collaboration Fund [PI; Jan-01-18 to Dec-31-19]: “Ovarian failure model and gut microbiota” (HK$200,000).
CAS-Croucher Funding Scheme for Joint Laboratories [PI; 01-Mar-17 to 28-Feb-19]: “Development of Human ESC/iPSC Models for Inducible Gene Editing Using the Latest CRISPR/Cas9 Technology” (HK$1,260,606).
NSFC/RGC Joint Research Scheme [PI; 01-Jan-17 to 31-Dec-20]: “Epigenetic Mechanism of Mitoflashes Facilitating Early Phase of Reprogramming” (HK$1,230,800).
TGD Life Company Limited [PI; 13-Sep-16 to 12-Sep-18]: “Biomedical Research of Prof. Chan Wai yee” (HK$100,000).
The Ministry of Science and Technology of China 973 [PI; 01-Sep-14 to 31-Aug-17]: “Stem cell therapy of liver diseases: An investigation (Project Awarded: RMB1,182,000, no funding transferred to CUHK) [NON_CU-PROJECT]” (RMB5,000,000).
Hong Kong Office of Hospital for Reproductive Medicine of Shandong University [PI; 05-Jan-14 to 04-Jan-18]: “General Education and Training in Reproductive Medicine” (HK$2,500,000).