姜洋子教授 – 生物醫學學院

姜洋子教授

Assistant Professor

School of Biomedical Sciences
Assistant Professor (by courtesy)
Orthopaedics & Traumatology

39435153

yangzjiang21@cuhk.edu.hk

https://www.iterm.cuhk.edu.hk/our-people/prof-jiang-yangzi/

http://jianglabrm.com/

Room 421A, 4/F, Lo Kwee-Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

Google Scholar

Publons

ORCID

个人简介

Prof. JIANG Yangzi (姜洋子) received Bachelor (2007, Biology) and PhD (2012, Sports Medicine) in Zhejiang University (ZJU), China, and was a postdoctoral associate (2012-2018) at University of Pittsburgh, USA. Prof. Jiang joined CUHK in 2018 and she is now an Assistant Professor of School of Biomedical Sciences (SBS), institute for Tissue Engineering and Regenerative Medicine (iTERM), and Assistant Professor (by courtesy) at Department of Orthopaedics & Traumatology (ORT).

Prof. Jiang has extensive multi-discipline expertise in basic scientific research, medical translational research and education in stem cells and regenerative medicine. Prof. Jiang’s research focused on creating tissue regeneration strategies of musculoskeletal system, and her publications cover the topics of stem cells, tissue engineering, cell transplantation, biomaterials, pathology of osteoarthritis, and translational medicine. Prof. Jiang has over 60 research outputs (H index 22, citation >2,300), serve as reviewer for more than 20 international journals and 3 international funding agencies. She has contributed to both textbooks and industrial guidelines to the field of Tissue Engineering and Regenerative Medicine, and her mentored students, doctors and scientists had been awarded with scholarships, research grants and honors from different universities, states, and countries (China, Australia, and United States).

Research Interests

Tissue engineering and regenerative medicine.
Cartilage and bone repair and regeneration.
Adult tissue specific stem/progenitor cells.
Regulating stem cells for cell-based therapy.
Regulators of stem cell aging.
Mechanism of osteoarthritis and other degenerative and inflammatory diseases.
Bioproducts for cell-based therapy.
From bench to bedside and to the bench – the pathway of translational medicine.

Selected Publications

1. Zhu, X., Cao, M., Li, K., Chan, Y.T., Chan, H.F., Mak, Y.W., Yao, H., Sun, J., Ong, T.Y.M., Ho, K.W.K., Lee, C.W., Lee, K.S.O., Yung, S.H.P., Jiang, Y.* (2024). Intra-articular Sustained-release of Pirfenidone with Bioactive Composites as a Disease-Modifying Treatment for Early Osteoarthritis. Bioactive Materials, Accepted, in press, IF: 18.9.
2. Huang, M., Zhou, J., Li, X., Liu, R., Jiang, Y., Chen, K., Jiao, Y., Yin, X., Liu, L., Sun, Y., Wang, W., Xiao, Y., Su, T., Guo, Q., Huang, Y., Yang, M., Wei, J., Quarles, L.D., Xiao, Z., Zeng, C., Luo, X., Lei, G., Li, C.* (2024). Mechanical protein polycystin-1 directly regulates osteoclastogenesis and bone resorption. Science Bulletin, in press, doi: 10.1016/j.scib.2024.04.044, IF: 18.9.
3. Zou, N., Liu, R., Huang, M., Jiao, Y., Wei, J., Jiang, Y., He, W., Huang, M., Xu, Y., Liu, L., Sun, Y., Yang, M., Guo, Q., Huang, Y., Su, T., Xiao, Y., Wang, W., Zeng, C., Lei, G., Luo., X.*, Li, C.* (2024). Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing. Bone Research, 12, 6., doi: 10.1038/s41413-023-00309-1, IF:16.4.
4. Jiang, Y.*, Tuan, R.* (2023). Bioactivity of Human Adult Stem Cells and Functional Relevance of Stem Cell-derived Extracellular Matrix in Chondrogenesis. Stem Cell Research & Therapy, 14,160, doi: 10.1186/s13287-023-03392-7.
5. Sun, J., Chan, Y.T., Ho, K.K.W., Zhang, L., Bian, L., Tuan, R.*, Jiang, Y.*. (2023). “Slow Walk” Mimetic Tensile Loading Maintains Human Meniscus Tissue Resident Progenitor Cells Homeostasis in Photocrosslinked Gelatin Hydrogel. Bioactive Materials, 25:256-272, doi:10.1016/j.bioactmat.2023.01.025, IF: 18.9.
6. Cao, M., Yao, S., Zhu, X., Ong, M. T.Y., Yung, S.H.P.*, Jiang, Y.*. (2023). Doxycycline Promotes Graft Healing and Attenuates Post-traumatic Osteoarthritis After Anterior Cruciate Ligament Reconstruction in a Rat Model. The American Journal of Sports Medicine, 51:2, doi: 10.1177/03635465221145015.
7. Li, K., Fan, L, Lin, J., Heng, B.C., Deng, Z., Zheng, Q., Zhang, J., Jiang, Y.*, Ge, Z.*. (2022). Nanosecond pulsed electric fields prime mesenchymal stem cells to peptide ghrelin and enhance chondrogenesis and osteochondral defect repair in vivo. Sci China Life Sci, 65(5):927-939, doi: 10.1007/s11427-021-1983-y, IF:10.372.
8. Cao, M., Ong, M.T.Y., Yung, P.S.H., Tuan, R.S., Jiang, Y.* (2022). Role of synovial lymphatic function in osteoarthritis. Osteoarthritis Cartilage, S1063-4584(22)00719-1, doi: 10.1016/j.joca.2022.04.003.
9. Jiang, Y.*. (2022). Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage, 30(2):207-215, doi: 10.1016/j.joca.2021.11.009.
10. Zhu, X., Chan, Y.T., Yung, S.H., Tuan, R.S.*, & Jiang, Y. *. (2020). Subchondral Bone Remodeling in Osteoarthritis. Frontiers in Cell & Developmental Biology , doi: 10.3389/fcell.2020.607764.
11. Jiang, Y.*, & Tuan, R.S.* (2019). Role of NGF/TrkA Signaling in Calcification of Articular Chondrocytes. The FASEB Journal, 33(9), 10231-10239, doi: 10.1096/fj.201900970.
12. Jiang, Y., Cai, Y., Zhang, W., Hu, C., Tong, T., Lu, P., Zhang, S., Neculai, D., Tuan, R., & Ouyang, H.W. (2016). Human Cartilage Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem Cells Translational Medicine, 5, 1-12, doi: 10.5966/sctm.2015-0192. [#Remark: This work reported the cell biology and results of human clinical study, and was specially reviewed and commented here]
13. Jiang, Y., Hu, C., Yu, S., Yan, J., Peng, H., Ouyang, H.W., & Tuan, R.S. (2015). Cartilage Stem/Progenitor Cells are Activated in Osteoarthritis via Interleukin-1β/Nerve Growth Factor Signaling. Arthritis Research and Therapy, 17, 327, doi: 10.1186/s13075-015-0840-x.
14. Jiang, Y., & Tuan, R.S. (2015). Origin and Function of Cartilage Stem/Progenitor Cells in Osteoarthritis. Nature Reviews Rheumatology, 11(4), 206-12, doi:10.1038/nrrheum.2014.200, IF:32.283.
15. Zhang, W., Heng, B.C., Jiang, Y.*, & Ouyang, H.W.* (2014). Clinical Translation of Autologous Cell-based Tissue Engineering Techniques as Class III Therapeutics in China: Taking Cartilage Tissue Engineering as An Example. Journal of Orthopaedic Translation, 2(2), 56-65, doi: 10.1016/j.jot.2014.02.002.

* Corresponding / Co-corresponding author

^# Co-first author

Google Scholar for Full Publication:
https://scholar.google.com/citations?hl=en&user=_JXDByoAAAAJ&view_op=list_works&sortby=pubdate

Grants

NSFC/RGC Joint Research Scheme [PI: 2023 to 2027]: “NSFC/RGC: N_CUHK483/22” (HK$ 1,244,750).
RGC – General Research Fund [PI: 2023 to 2026]: “GRF14104022” (HK$ 1,180,218).
ITC – Health@InnoHK – The Center for Neuromusculoskeletal Restorative Medicine (CNRM)[Co-PI: 2022 to 2027].
Ministry of Science and Technology (MOST) of China, National Key R&D Program, Young Scientist Scheme (国家重点研发计划“干细胞与转化医学”重点专项,青年科学家项目)[PI; 2019 to 2023]: “Stem Cells and Translational Medicine” 2019YFA0111900 (RMB$5,450,000).

Awards

National Key Research and Development (R&D) Program, Young Scientist Scheme, awarded by Ministry of Science and Technology (MOST) of China, China (2019-11) 国家重点研发计划 “干细胞与转化医学”重点专项，首席青年科学家 [1/1] .
2nd Prize, COA Orthopaedics Youth Research Award (2018), Chinese Medical Association, Chinese Orthopaedic Association, The 13th Annual Congress of Chinese Orthopaedic Association, China 11/2018 中华医学会骨科学分会骨科基础青年研究奖 [1/1].
1st Prize, 10th “Chunhui Cup” Innovation and Entrepreneurship Competition (2015) for Oversea Chinese Scholars, North America Division (New York Consular District), Ministry of Education & Ministry of Science and Technology of China, 11/2015 [2/6].
4th Award Winner, RFBI Competition (2015), innovation Institute, University of Pittsburgh, PA, United States, 06/2015 [4/4] .
1st Prize, Science and Technology Progress Award, Ministry of Education, China, 01/2013 [3/9] 中华人民共和国教育部科技进步一等奖 (第3完成人，证书编号：2012-173).
Endeavour Research Fellowship, the Merit-based Endeavour Award, Ministry of Education, Australia 01/2012 [1/1] .
Outstanding Ph.D. graduate of Zhejiang Province, Zhejiang, China, 06/2012 [1/1] .
Qiu-Shi Academic Star (求是学术之星), Zhejiang University, China, 06/2011 [1/1, top 0.05%] .