关耀华教授 – 生物醫學學院

关耀华教授

Senior Research Fellow

B.Sc., Ph.D.

39436884

yiuwakwan@cuhk.edu.hk

207A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Publons

ORCID

个人简介

Prof. KWAN Yiu Wa (关耀华) obtained his Bachelor degree (Hons) from the Department of Pharmacology and Experimental Therapeutics of The Liverpool University (UK), and his PhD degree in the Department of Pharmacology and Physiology of The Strathclyde University (Glasgow, Scotland) after he received a scholarship from the Croucher Foundation. He went on to have his post-doctoral training, with the supports of the American Heart Association (USA), under Professor R.S. Kass (University of Rochester New York, New York, USA) prior to joining The Chinese University of Hong Kong. He is a pharmacologist by training, and his main research interests are related to the pharmacology of different drugs in treating metabolic and vascular diseases e.g. type 2 diabetes mellitus, osteoporosis and pulmonary hypertension. He also has research interests in the utilization of alternative / un-conventional approaches such as recombinant probiotics in treating various diseases.

Research Interests

Diabetes Mellitus: Development and treatments (Western medicines and Natural / herbal Products).
Osteoporosis: Development and treatments (Western medicines and Natural / herbal Products).
Cardiovascular diseases: Drug treatments (Western medicines and Natural / herbal Products).
Cancers Biology: Development and treatments (Western medicines and Natural / herbal Products).
Development of recombinant probiotics for therapeutic uses.

Selected Publications

Vong, C.T., Tseng, H.H.L., Kwan, Y.W. , Lee, S.M.Y., Hoi, M.P.M. (2019). G-protein coupled receptor 55 agonists increase insulin secretion through inositol trisphosphate-mediated calcium release in pancreatic β-cells. European Journal of Pharmacology, 854, 372-379.
Yeung, K.W., Lau, P.M., Tsang, H.L., Ho, H.P., Kwan, Y.W. , Kong, S.K. (2019). Extracellular Histones Induced Eryptotic Death in Human Erythrocytes. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 53, 1, 229-241.
Chan, B.D., Wong, W.Y., Lee, M.M.L., Cho, W.C.S., Yee, B.K., Kwan, Y.W. , Tai, W.C.S. (2019). Exosomes in Inflammation and Inflammatory Disease. Proteomics, 19, 1-12.
Vong, C.T., Tseng, H.H.L., Kwan, Y.W. , Lee, S.M.Y., Hoi, M.P.M. (2019). Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 111, 1176-1186.
Liang, C., Zhang, Y., Zhuo, D., Lo, C.Y., Yu, L., Lau, C.W., Kwan, Y.W. , Tse, G., Huang, Y., Yao, X. (2019). Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries. Biochemical Pharmacology, 159, 11-24.
Zhou, Z., Huang, B., Li, S., Huang, X., Tang, J., Kwan, Y.W. , Hoi, P.M., Lee, S.M.Y. (2018). Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish. Toxicology and applied pharmacology, 350, 32-42.
Law, I.L.G., Loo, J.F.C., Kwok, H.C., Yeung, H.Y., Leung, C.C.H., Hui, M., Wu, S.Y., Chan, H.S., Kwan, Y.W. , Ho, H.P., Kong, S.K. (2018). Automated real-time detection of drug-resistant Mycobacterium tuberculosis on a lab-on-a-disc by Recombinase Polymerase Amplification. Analytical biochemistry, 544, 98-107.
Gao, L., Kwan, Y.W. , Bulmer, A.C., Lai, C.W.K. (2018). Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment. Oxidative medicine and cellular longevity, 2018, 8267560.
Chan, J.Y.W., Zhou, H., Kwan, Y.W. , Chan, S.W., Radis-Baptista, G., Lee, S.M.Y. (2017). Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. Journal of biochemical and molecular toxicology, 31, 11, e21964.
Tseng, H.H.L., Vong, C.T., Kwan, Y.W., Lee, S.M., & Hoi, M.P.M. (2017). Lysosomal Ca²⁺ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells. Front Immunol, 8, 1161.
Li, S., Ai, N., Shen, M., Dang, Y., Chong, C.M., Pan, P., Kwan, Y.W., Chan, S.W., Leung, G.P.H, Hoi, M.P.M., Hou, T., & Lee, S.M. (2017). Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discov, 3, 17051.
Chan, J.Y., Zhou, H., Kwan, Y.W., Chan, S.W., Radis-Baptista, G., & Lee, S.M. (2017). Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics. J Biochem Mol Toxicol, 31(11), doi: 10.1002/jbt.21964.
Steiner, G.Z., Seto, S.W., Kwan, Y.W., Haskell-Ramsay, C., & Camfield D.A. (2017). Complementary Medicine for the Modification of Risk Factors for Cognitive Impairment. Evid Based Complement Alternat Med, 2017, 9472859.
Zhou, X., Cui, G., Tseng, H.H., Lee, S.M., Leung, G.P., Chan, S.W., Kwan, Y.W., & Hoi, M.P. (2016). Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine. Evid Based Complement Alternat Med, 2016, 9627258.
Tseng, H.H., Vong, C.T., Leung, G.P., Seto, S.W., Kwan, Y.W., Lee, S.M., & Hoi, M.P. (2016). Calycosin and Formononetin Induce Endothelium-Dependent Vasodilation by the Activation of Large-Conductance Ca²⁺-Activated K⁺-Channels (BKCa). Evid Based Complement Alternat Med, 2016, 5272531.
Tang, P.C., Yang, C., Li, R.W., Lee, S.M., Hoi, M.P., Chan, S.W., Kwan, Y.W., Tse, C.M., & Leung, G.P. (2016). Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine. Eur J Pharmacol, 791, 544-551.
Tseng, H.H., Vong, C.T., Kwan, Y.W., Lee, S.M., & Hoi, M.P. (2016). TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep, 6, 35016.
Zhou, X., Choi, P.S., Yang, J.M., Or, P.M., Hoi, P.M., Lee, S.M., Leung, G.P., Ngai, S.M., Kong, S.K., Ho, H.P., Wong, M.Y., Chan, S.W., Yeung, J.H., & Kwan, Y.W. (2016). Chemical and pharmacological evaluations on the extract of Scutellaria baicalensis Georgi (Huang-Qin) prepared by various extraction methods. Springerplus, 5(1), 1438.
Vong, C.T., Tseng, H.H., Kwan, Y.W., Lee, S.M., & Hoi, M.P. (2016). Antrodia camphorata Increases Insulin Secretion and Protects from Apoptosis in MIN6 Cells. Front Pharmacol, 7, 67.
Li, S., Dang, Y., Zhou, X., Huang, B., Huang, X., Zhang, Z., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M., & Hoi, M.P. (2015). Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway. Sci Rep, 5, 16815.
Poon, C.C., Li, R.W., Seto, S.W., Kong, S.K., Ho, H.P., Hoi, M.P., Lee, S.M, Ngai, S.M., Chan, S.W., Leung, G.P., & Kwan, Y.W. (2015). In vitro vitamin K2 and 1a,25-dihydroxyvitamin D3 combination enhances osteoblasts anabolism of diabetic mice. Eur J Pharmacol, 767, 30-40.
Zhou, X., Wang, Y., Lee, W.Y., Or, P.M., Wan, D.C., Kwan, Y.W., & Yeung, J.H. (2015). Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in oxorubicin-Resistant HepG2 Cells. J Nat Prod, 78(9), 2266-75.
Seto, S.W., Yang, G.Y., Kiat, H., Bensoussan, A., Kwan, Y.W., & Chang, D. (2015). Diabetes Mellitus, Cognitive Impairment, and Traditional Chinese Medicine. Int J Endocrinol, 2015, 810439.
Li, R.W., Yang, C., Shan, L., Zhang, Z., Wang, Y., Kwan, Y.W., Lee, S.M., Hoi, M.P., Chan, S.W., Cheung, A.C., Cheung, K.H., & Leung, G.P. (2015). Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries. Eur J Pharmacol, 761, 153-60.
Li, R.W., Yang, C., Chan, S.W., Hoi, M.P., Lee, S.M., Kwan, Y.W., & Leung, G.P. (2015). Relaxation effect of abacavir on rat basilar arteries. PLoS One, 10(4), e0123043.
Hu, T., Zhou, X., Wang, L., Or, P.M., Yeung, J.H., Kwan, Y.W., & Cho C.H. (2015). Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies. Chem Biol Interact, 230, 1-8.
Li, S., Zhou, X.L., Dang, Y.Y., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M., & Hoi, M.P. (2015). Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochim Biophys Acta, 850(2), 373-84.
Hoi, P.M., Li, S., Vong, C.T., Tseng, H.H., Kwan, Y.W., & Lee, S.M. (2015). Recent advances in structure-based drug design and virtual screening of VEGFR tyrosine kinase inhibitors. Methods, 71, 85-91.
Li, S., Dang, Y.Y., Oi, Lam, Che, G., Kwan, Y.W., Chan, S.W., Leung, G.P., Lee, S.M., & Hoi MP. (2014). VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol, 280(3), 408-20.
Ho, H.P., Lau, P.M., Kwok, H.C., Wu, S.Y., Gao, M., Cheung, A.K., Chen, Q., Wang, G., Kwan, Y.W., Wong, C.K., & Kong, S.K. (2014). Allergen screening bioassays: recent developments in lab-on-a-chip and lab-on-a-disc systems. Bioanalysis, 6(14), 2005-18.

Grants

RGC – General Research Fund [PI; 01-Jan-14 to 31-Dec-16]: “A Novel Combination Therapy for Treating Osteoporosis – A Mechanistic Study on the Synergistic Bone Anabolic Effects of HMG CoA Reductase Inhibitor and Vitamin D” (HK$770,769).