Prof Stephen DALTON – 生物醫學學院

Prof Stephen DALTON

Professor/Global STEM Scholar

B.Sc. Hons., Ph.D.

39430537

sdalton@cuhk.edu.hk

Room 223A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

ORCID

个人简介

Prof. Stephen DALTON (杜卓勋) is a Professor in the School of Biomedical Sciences and has research interests in stem cell and developmental biology and the use of stem cells in regenerative medicine and therapeutic development. Prof. Dalton received his Ph.D. from the University of Adelaide in Australia, followed by post-doctoral research at the Imperial Cancer Research Fund in London with Sir Richard Treisman. Following this, Prof. Dalton joined Hoffman La Roche in Nutley, New Jersey and worked closely with large ‘pharma’ on a broad range of projects while at the Roche Institute for Molecular Biology. Then, after taking an academic position in Australia, Prof. Dalton moved to the University of Georgia where he was for 19 years. During this time, he was founding director of the Center for Molecular Medicine. At CUHK, Dr. Dalton continues his work in adult and pluripotent stem cell biology and has initiated a program focused on therapeutic development for type 2 diabetes using technology developed in his laboratory.

Research Interests

Pluripotent and adult stem cells
Cardiac development
Brown and beige adipocytes
Therapeutic development for type 2 diabetes

Career Opportunities

The Dalton laboratory uses adult and pluripotent stem cells to understand mechanisms of cell fate determination and as a platform to develop therapeutics for metabolic disease and obesity. They are looking for highly motivated and talented scientists to apply for the posts of Research Assistant Professor, Postdoctoral Fellow(s) and Research Assistant(s), as well as looking for Postgraduate Student(s). The details and application method can be viewed here:

Research Assistant Professor
Postdoctoral Fellow(s)
Research Assistant(s)
Postgraduate Student(s)
Requirements: Interests in cell and developmental biology, stem cells, molecular medicine
General areas:
1. Understanding molecular mechanisms for how stem cells can generate therapeutically useful cell types
2. Development of therapies for type 2 diabetes using stem cells

For additional information on research projects in the Dalton laboratory, please visit www.daltonlab.uga.edu or contact Prof. Stephen Dalton at sdalton@cuhk.edu.hk.

Selected Publications

Fagnocchi, L., Cherubini, A., Hatsuda, H., Fasciani, A., Mazzoleni, S., Poli, V., Berno, V., Rossi, R.L., Reinbold, R., Endele, M., Schroeder, T., Rocchigiani, M., Szkarłat, Ż., Oliviero, S., Dalton, S. and Zippo, A. (2016). A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun., 7, 11903.
Berger, R.P., Sun, Y.H., Kulik, M., Lee, J.K., Nairn, A.V., Moremen, K.W., Pierce, M. and Dalton, S. (2016). ST8SIA4-Dependent polysialylation is art of a developmental program required for germ layer formation from pluripotent stem cells. Stem Cells, 34, 1742-1752.
Ter Huurne, M., Chappell, J., Dalton, S. and Stunnenberg, H.G. (2017). Distinct cell-cycle control in two different states of mouse pluripotency. Cell Stem Cell, 21, 449-455.
Cliff, T.S., Wu, T., Boward, B.R., Yin, A., Yin, H., Glushka, J.N., Prestegaard, J.H. and Dalton, S. (2017). MYC controls human pluripotent stem cell fate decisions through regulation of metabolic flux. Cell Stem Cell, 21, 502-516.
Dileep, V., Wilson, K.A., Marchal, C., Lyu, X., Zhao, P.A., Li, B., Poulet, A., Bartlett, D.A., Rivera-Mulia, J.C., Qin, Z.S., Robins, A.J., Schulz, T.C., Kulik, M.J., McCord, R.P., Dekker, J., Dalton, S., Corces, V.G. and Gilbert, D.M. (2019). Rapid irreversible transcriptional reprogramming in human stem cells accompanied by discordance between replication timing and chromatin compartment. Stem Cell Reports, 13, 193-206.
Colunga, T., Hayworth, M., Kreß, S., Reynolds, D.M., Chen, L., Nazor, K.L., Baur, J., Singh, A.S., Loring, J.F., Metzger, M and Dalton, S. (2019). Human pluripotent stem cell-derived multipotent vascular progenitors of the mesothelium lineage have utility in tissue engineering and vascular repair. Cell Reports, 26, 2566-2579.
Singh, A.M., Zhang, L., Avery, J., Yin, A., Du, Y., Wang, H., Li, Z., Fu, H., Yin, H. and Dalton, S. (2020). Human beige adipocytes generated from adipose-derived stem cells have utility for drug discovery and cell therapy of metabolic diseases. Nat. Commun., 11, 2758.
ENCODE Project Consortium, Snyder, M.P., Gingeras, T.R., Moore, J.E., Weng, Z. et al. (2020). Perspectives on ENCODE. Nature, 583, 693-698.
Grubert, F., Srivas, R., Spacek, D.V., Kasowski, M., Ruiz-Velasco, M., Sinnott-Armstrong, N., Greenside, P., Narasimha, A., Liu, Q., Geller, B., Sanghi, A., Kulik, M., Sa, S., Rabinovitch, M., Kundaje, A., Dalton, S., Zaugg, J.B., Snyder, M. (2020). Landscape of cohesin-mediated chromatin loops in the human genome. Nature, 583, 737-743.
ENCODE Project Consortium, Moore, J.E., Purcaro, M.J., Pratt, H.E., Epstein, C.B., et al. (2020). Expanded encyclopedias of DNA elements in the human and mouse genomes. Nature, 583, 699-710.
Zhang, L., Avery, J., Yin, A., Singh, A.S., Cliff, T.S., Yin, H. and Dalton, S. (2020). Generation of functional brown adipocytes through a directed developmental progression of human pluripotent stem cells. Cell Stem Cell, 27, 784-797.
K.N., Kyle N., Zhao, P.A., Lyu, X., Sasaki, T., Bartlett, D.A., Singh, A., Tasan, I., Zhang, M., Watts, L.P., Hiraga, S-I., Natsume, T., Zhou, X., Leung, D., Kanemaki, M.T., Donaldson, A.D., Zhao, H. Dalton, S., Corces, V. and Gilbert, D.M. (2021). Replication timing maintains the global epigenetic state in human cells. Science, 372, 371-378.

Grants

National Institute for General Medical Science (NIGMS) [PI; 01-Jan-15 – 31-Dec-20]: “Understanding mechanisms of human pluripotent stem cell self-renewal and cell fate determination”, (HK$70,992,500).
National Institute for General Medical Science (NIGMS) [PI; 01-Jul-15 – 30-Jun-20]: “National Center for Biomedical Glycomics: Glycobiology of pluripotent stem cells”, (HK$9,336,000).
National Human Genome Research Institute (NHGRI) ENCODE Consortium Pilot Project [PI; 01-Jul-19 – 30-Dec-20]: “Landscape of transcription in human and mouse”, (HK$1,244,800).
Georgia Research Alliance (GRA): Technology seed grant – phase 1 [PI; 01-Jul-20 – 30-Jun-21]: “Cell-based screens for diabetes and obesity”, (HK$583,500).
Nestle’ Institute of Health Sciences (NIHS, Lausanne, Switzerland): Large Project Support [PI; 01-Jun-18 – 31-May-21]: “Technology development for generation of human thermogenic adipocytes”, (HK$5,057,000).
University of Illinois/Abbott Laboratories [PI; 01-Oct 19 – 30-Mar-21]: “Understanding the effects of nutritional supplements on function and development of human neuronal cells”, (HK$4,714,680).
Keck Foundation [PI; 01-Jul-16 – 31-Dec-17]: “The Glycomics of Human Neurodegenerative, Developmental, and Cognitive Disorders”, (HK$1,213,680).

个人简介

Opportunities at the Dalton laboratory