王武明教授 – 生物醫學學院

王武明教授

Research Assistant Professor

B.Sc., M.Sc., Ph.D.

39430570

wangwuming@cuhk.edu.hk

125A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, CUHK

Publons

ORCID

个人简介

Prof. WANG Wuming (王武明) received his B.Sc. in Biological Science from Nanchang University in 2011 and completed his M.Sc. in Biology from Shanghai Jiao Tong University in 2014. Thereafter he obtained his Ph.D. degree from Department of Surgery at the Chinese University of Hong Kong (CUHK) in 2017. After graduation, he pursued postdoc training in Prof. Chan Wai-yee’s laboratory at the School of Biomedical Sciences in CUHK for four years and became a Research Assistant Professor in 2021. Dr. Wang’s research work has focused on the regulatory mechanism of pluripotency maintenance in embryonic stem cells. He has also revealed a dynamic change of non-CG DNA methylation during cardiomyocyte differentiation. Dr. Wang has published papers in international journals including Advanced Science, Cell Death & Disease, and Frontiers in Cellular Neuroscience. His current research interests are ESC pluripotency, cardiac development and disease, and exploration of the development and translational application of genome editing tools.

Research Interests

The regulatory mechanism of the maintenance of ESC pluripotency
Cardiac development and disease
The development and translational application of genome editing tools

Selected Publications

Lu G, Su X, Wang L, Leung CK, Zhou J, Xiong Z, Wang W, Liu H, Chan WY. (2023). Neuroprotective Effects of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Extracellular Vesicles in Ischemic Stroke Models. Biomedicines, 11(9):2550.
Yin Z, Cui S, Xue S, Xie Y, Wang Y, Zhao C, Zhang Z, Wu T, Hou G, Wang W, Xie SQ, Wu Y, Guo Y. (2023). Identification of Two Subsets of Subcompartment A1 Associated with High Transcriptional Activity and Frequent Loop Extrusion. Biology (Basel), 12(8):1058.
Tian Y, Wang W, Lautrup S, Zhao H, Li X, Law PWN, Dinh ND, Fang EF, Cheung HH, Chan WY. (2022). WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nat Commun. 13(1):5456.
Chen X, Zhou C, Xu D, Liu X, Li S, Hou J, Zhang K, Zeng C, Zheng G, Wu H, Wu H, Wang W, Fu J, Wang T. (2022), Peptide hormone ELABELA promotes rat bone marrow-derived mesenchymal stem cell proliferation and migration by manipulating the cell cycle through the PI3K/AKT pathway under the hypoxia and ischemia microenvironment. Stem Cell Res Ther, 13(1):32.
Cao RC, Lv Y, Lu G, Liu HB, Wang W, Tan C, Su XW, Xiong Z, Ma JL, Chan WY. (2023). Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway. Zool Res, 44(3):620-635.
Wang W, Lu G, Liu HB, Xiong Z, Leung HD, Cao R, Pang AL, Su X, Law PWN, Zhao Z, Chen ZJ, Chan WY. (2021). Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3. Adv Sci, e2100849.
Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY. (2020). Pten-mediated Gsk3beta modulates the naive pluripotency maintenance in embryonic stem cells. Cell Death Dis., 11(2): 107.
Cao, L.B., Liu, H.B., Lu, G., Lv, Y., Leung C.K., Du, Y.Z., Wang, W.M., Xiong, Z.Q., Su, X.W., Li, H.J., Chen, Z.J., Ma, J.L., & Chan, W.Y. (2020). Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development. Front Cell Dev Biol., 8: 587.
Fu J, Chen X, Liu X, Xu D, Yang H, Zeng C, Long H, Zhou C, Wu H, Zheng G, Wu H, Wang W, Wang T. (2020). ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways. Stem Cell Res Ther., 11(1): 541.
Tang CC, Shan LP, Wang WM, Lu G, Tare RS, Lee KKH. (2017). Generation of a Bag1 homozygous knockout mouse embryonic stem cell line using CRISPR/Cas9. Stem Cell Res., 21: 29-31.
Wang WM, Lu G, Su XW, Lyu H, Poon WS. (2017). MicroRNA-182 Regulates Neurite Outgrowth Involving the PTEN/AKT Pathway. Front Cell Neurosci, 11: 96.

Grants

ITF-TCFS [PI; Apr-23 to Mar-25]: “Research and Application of Genetic Screening in Precise Diagnosis and Treatment of Methylmalonic Acidemia” (HK$882,550).
NSFC Youth Program [PI; Jan-23 to Dec-25]: “Elucidating the roles of Pten in cardiac fibroblast generation and myocardial fibrosis”, National Natural Science Foundation of China (RMB$300,000).
NSFC/RGC JRS [Co-PI; Jan-23 to Dec-26]: “Study the Roles of Mitochondrial DNA Methylation in Regulating Nucleoid Phase Separation and Transcription Modulation” (HK$1,125,254).