夏银教授 – 生物醫學學院

夏银教授

Research Associate Professor

39434480

Xia.Yin@cuhk.edu.hk

Room 620A, 6/F., Lo Kwee Seong Integrated Biomedical Sci. Bldg, Area 39, CUHK

ORCID

个人简介

Prof. XIA Yin (夏银) joined the School of Biomedical Sciences (SBS) of The Chinese University of Hong Kong as Assistant Professor, and he is at present Research Associate Professor. He obtained his Ph.D. in Physiology from the University of New England, Australia, and he then moved to Massachusetts General Hospital, Harvard Medical School, to work as Postdoctoral Fellow and Instructor for several years. Yin was interested in understanding the functions of activins and BMPs in a number of biological systems including the gonads, iron metabolism and the kidney. Yin’s current research focuses on elucidating the molecular mechanisms of kidney injury and repair, and dissecting the various effects of inflammation on metabolism. Yin has published papers in many journals including Nature Genetics, Blood, Cell Death and Differentiation, PNAS, J Am Soc Nephrol, and Kidney International.

Research Interests

Kidney physiology, injury and repair
Male reproductive biology
Metabolic signaling pathways in the liver

Selected Publications

1. Liu, Y., Wang, Y., Xu, C., Zhang, Y., Wang, Y., Qin, J., Lan, H.Y., Wang, L., Huang, Y., Mak, K.K.*, Zheng, Z.*, Xia, Y.* (2024). Activation of the YAP/KLF5 transcriptional cascade in renal tubular cells aggravates kidney injury. Mol Ther., 32(5), 1526-1539.
2. Zhang, Y., Huang, H., Kong, Y., Xu, C., Dai, L., Geng, X., Deng, Y., Wang, Y., Liu, Y., Meng, C., Zhang, X., Li, J., Qin, J., Feng, B., Mak, K.K., Wang, L., Huang, Y., Wang, W., Lan, H.Y., Yang, B., Lu, H.A.J., Xia, Y.* (2023). Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis. Kidney Int.103(3):501-513. With a Commentary.
3. Meng, C., Tian, G., Xu, C., Li, X., Zhang, Y., Wang, Y., Qin, J., Fok, E.K.L., Hinton, B.T., Mak, K.K., Shum, W.W., Chan, W.Y., Xia, Y.* (2020). Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway. Cell Death Differ, 27, 2797-2809.
4. Xu, C., Wang, L., Zhang, Y., Li, W., Li, J., Wang, Y., Meng, C., Qin, J., Zheng, Z.H., Lan, H.Y., Mak, K.K., Huang, Y., Xia, Y.* (2020). Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms. J Am Soc Nephrol, 31(5) 946-961. With an Editorial.
5. Meng, C., Liao, J., Zhao, D., Huang, H., Qin, J., Lee, T.L., Chen, D., Chan, W.Y., Xia, Y.* (2019). L3MBTL2 regulates chromatin remodeling during spermatogenesis. Cell Death Differ, 26, 2194-2207.
6. Liu, W., Chen, B., Wang, Y., Meng, C., Huang, H., Huang, X.R., Qin, J., Mulay, S.R., Anders, H.J., Qiu, A., Yang, B., Freeman, G.J., Lu, H.J., Lin, H.Y., Zheng, Z.H., Lan, H.Y., Huang, Y., Xia, Y.* (2018). RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A (direct submission), 115(7), E1475-E1484.
7. Huang, H., Xu, C., Wang, Y., Meng, C., Liu, W., Zhao, Y., Huang, X.R., You, W., Feng, B., Zheng, Z.H., Huang, Y., Lan, H.Y., Qin, J.*, Xia, Y.* (2018). Lethal (3) malignant brain tumor like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney International, 93(4), 855-870.
8. Wu, X.G., Wang, Y., Wu, Q., Cheng, W.H., Liu, W., Zhao, Y., Mayeur, C., Schmidt, P.J., Yu, P.B., Wang, F., Xia Y.* (2014). HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood, 124(8), 1335-43. With an inside Blood commentary.
9. Liu, W., Li, X., Zhao, Y., Meng, X.M., Wan, C., Yang, B., Lan, H.Y., Lin, H.Y., Xia, Y.* (2013). Dragon (RGMb) inhibits E-Cadherin expression and induces apoptosis in renal tubular epithelial cells. J Biol Chem, 288(44), 31528-39.
10. Xia, Y.*, Cortez-Retamozo, V., Niederkofler, V., Salie, R., Chen, S., Samad, T.A., Hong, C.C., Arber, S., Vyas, J.M., Weissleder, R., Pittet, M.J., Lin, H.* (2011). Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol, 186(3), 1369-1376.
11. Xia, Y., Babitt, J.L., Bouley, R., Zhang, Y., Da, Silva N., Chen, S., Zhuang, Z., Samad, T.A., Brenner, G.J., Anderson, J.L., Hong, C.C., Schneyer, A.L., Brown, D., Lin, H.Y. (2010). Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol, 21(4), 666-677.
12. Andriopoulos, B. Jr.#, Corradini, E.#, Xia, Y.#, Faasse, S.A., Chen, S., Grgurevic, L., Knutson, M.D., Pietrangelo, A., Vukicevic, S., Lin, H.Y., Babitt, J.L. (2009) BMP-6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nature Genetics, 41(4), 482-487.
13. Xia, Y., Babitt, J.L., Sidis, Y., Chung, R.T., Lin, H.Y. (2008). Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood, 111(10), 5195-5204.
14. Xia, Y., Yu, P.B., Sidis, Y., Beppu, H., Bloch, K.D., Schneyer, A.L., Lin, H.Y. (2007). Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282(25), 18129-18140.
15. Xia, Y., Sidis, Y., Mukherjee, A., Samad, T.A., Brenner, G., Woolf, C.J., Lin, H.Y., Schneyer, A. (2005). Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology, 146(8), 3614-3621.
16. Xia, Y., Sidis Y., Schneyer, A. (2004). Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice. Mol Endocrinol, 18(4), 979-94.

* Co-correspondence author
# Co-first author

Grants

RGC – General Research Fund [PI; 01-Nov-2020 to 31-Oct-2023]: “The role and mechanisms of tubular YAP activation in renal fibrosis” (HK$ 996,285).
Health and Medical Research Fund [PI; 01-Jun-2020 to 31-May-2023]: “Role of IL-1b in hepatic FGF19 signaling and metabolic functions” (HK$ 1,498,404).